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In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography

The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical...

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Autores principales: Eberle, Melissa M., Reynolds, Carissa L., Szu, Jenny I., Wang, Yan, Hansen, Anne M., Hsu, Mike S., Islam, M. Shahidul, Binder, Devin K., Park, B. Hyle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493229/
https://www.ncbi.nlm.nih.gov/pubmed/23162709
http://dx.doi.org/10.1364/BOE.3.002700
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author Eberle, Melissa M.
Reynolds, Carissa L.
Szu, Jenny I.
Wang, Yan
Hansen, Anne M.
Hsu, Mike S.
Islam, M. Shahidul
Binder, Devin K.
Park, B. Hyle
author_facet Eberle, Melissa M.
Reynolds, Carissa L.
Szu, Jenny I.
Wang, Yan
Hansen, Anne M.
Hsu, Mike S.
Islam, M. Shahidul
Binder, Devin K.
Park, B. Hyle
author_sort Eberle, Melissa M.
collection PubMed
description The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical changes, specifically changes in near-infrared optical scattering, may precede EEG seizure onset in in vivo models. Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth resolved cross-sectional images. In this study, OCT was used to detect changes in optical properties of cortical tissue in vivo in mice before and during the induction of generalized seizure activity. We demonstrated that a significant decrease (P < 0.001) in backscattered intensity during seizure progression can be detected before the onset of observable manifestations of generalized (stage-5) seizures. These results indicate the feasibility of minimally-invasive optical detection of seizures with OCT.
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spelling pubmed-34932292012-11-16 In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography Eberle, Melissa M. Reynolds, Carissa L. Szu, Jenny I. Wang, Yan Hansen, Anne M. Hsu, Mike S. Islam, M. Shahidul Binder, Devin K. Park, B. Hyle Biomed Opt Express Neuroscience and Brain Imaging The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical changes, specifically changes in near-infrared optical scattering, may precede EEG seizure onset in in vivo models. Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth resolved cross-sectional images. In this study, OCT was used to detect changes in optical properties of cortical tissue in vivo in mice before and during the induction of generalized seizure activity. We demonstrated that a significant decrease (P < 0.001) in backscattered intensity during seizure progression can be detected before the onset of observable manifestations of generalized (stage-5) seizures. These results indicate the feasibility of minimally-invasive optical detection of seizures with OCT. Optical Society of America 2012-10-02 /pmc/articles/PMC3493229/ /pubmed/23162709 http://dx.doi.org/10.1364/BOE.3.002700 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Neuroscience and Brain Imaging
Eberle, Melissa M.
Reynolds, Carissa L.
Szu, Jenny I.
Wang, Yan
Hansen, Anne M.
Hsu, Mike S.
Islam, M. Shahidul
Binder, Devin K.
Park, B. Hyle
In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
title In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
title_full In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
title_fullStr In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
title_full_unstemmed In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
title_short In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
title_sort in vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
topic Neuroscience and Brain Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493229/
https://www.ncbi.nlm.nih.gov/pubmed/23162709
http://dx.doi.org/10.1364/BOE.3.002700
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