Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs

BACKGROUND: Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation. However, it is unclear if growth hormone and insulin, well known for their implication in short bowel pa...

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Autores principales: Papamichail, Michail, Digalakis, Michail, Panagiotis, Prigouris, Paisios, Odysseas, Loti, Soyltana, Sergentanis, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493264/
https://www.ncbi.nlm.nih.gov/pubmed/22929117
http://dx.doi.org/10.1186/1756-0500-5-463
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author Papamichail, Michail
Digalakis, Michail
Panagiotis, Prigouris
Paisios, Odysseas
Loti, Soyltana
Sergentanis, Theodoros
author_facet Papamichail, Michail
Digalakis, Michail
Panagiotis, Prigouris
Paisios, Odysseas
Loti, Soyltana
Sergentanis, Theodoros
author_sort Papamichail, Michail
collection PubMed
description BACKGROUND: Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation. However, it is unclear if growth hormone and insulin, well known for their implication in short bowel pathophysiology, intervene on this effect. FINDINGS: Porcine models were randomly allocated to two cohorts: (1) short bowel (SB) group (n = 8) and (2) short bowel reverse jejunal segment (SB-RS) group (n = 8). Amongst other parameters serum growth hormone and insulin were measured at baseline, as well as on postoperative day 30 and 60. CONCLUSION: Both endogenous hormones failed to demonstrate significant difference in respect to potential direct effect to mechanisms of enhanced intestinal adaptation in reversed group
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spelling pubmed-34932642012-11-09 Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs Papamichail, Michail Digalakis, Michail Panagiotis, Prigouris Paisios, Odysseas Loti, Soyltana Sergentanis, Theodoros BMC Res Notes Short Report BACKGROUND: Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation. However, it is unclear if growth hormone and insulin, well known for their implication in short bowel pathophysiology, intervene on this effect. FINDINGS: Porcine models were randomly allocated to two cohorts: (1) short bowel (SB) group (n = 8) and (2) short bowel reverse jejunal segment (SB-RS) group (n = 8). Amongst other parameters serum growth hormone and insulin were measured at baseline, as well as on postoperative day 30 and 60. CONCLUSION: Both endogenous hormones failed to demonstrate significant difference in respect to potential direct effect to mechanisms of enhanced intestinal adaptation in reversed group BioMed Central 2012-08-28 /pmc/articles/PMC3493264/ /pubmed/22929117 http://dx.doi.org/10.1186/1756-0500-5-463 Text en Copyright ©2012 Papamichail et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Papamichail, Michail
Digalakis, Michail
Panagiotis, Prigouris
Paisios, Odysseas
Loti, Soyltana
Sergentanis, Theodoros
Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs
title Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs
title_full Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs
title_fullStr Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs
title_full_unstemmed Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs
title_short Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs
title_sort endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. an experimental study on pigs
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493264/
https://www.ncbi.nlm.nih.gov/pubmed/22929117
http://dx.doi.org/10.1186/1756-0500-5-463
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