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Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes

BACKGROUND: The Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) constitute an apparently monophyletic group that consists of at least 6 families of viruses infecting a broad variety of eukaryotic hosts. A comprehensive genome comparison and maximum-likelihood reconstruction of the NCLDV evolution revea...

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Autores principales: Yutin, Natalya, Koonin, Eugene V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493329/
https://www.ncbi.nlm.nih.gov/pubmed/22891861
http://dx.doi.org/10.1186/1743-422X-9-161
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author Yutin, Natalya
Koonin, Eugene V
author_facet Yutin, Natalya
Koonin, Eugene V
author_sort Yutin, Natalya
collection PubMed
description BACKGROUND: The Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) constitute an apparently monophyletic group that consists of at least 6 families of viruses infecting a broad variety of eukaryotic hosts. A comprehensive genome comparison and maximum-likelihood reconstruction of the NCLDV evolution revealed a set of approximately 50 conserved, core genes that could be mapped to the genome of the common ancestor of this class of eukaryotic viruses. RESULTS: We performed a detailed phylogenetic analysis of these core NCLDV genes and applied the constrained tree approach to show that the majority of the core genes are unlikely to be monophyletic. Several of the core genes have been independently acquired from different sources by different NCLDV lineages whereas for the majority of these genes displacement by homologs from cellular organisms in one or more groups of the NCLDV was demonstrated. CONCLUSIONS: A detailed study of the evolution of the genomic core of the NCLDV reveals substantial complexity and diversity of evolutionary scenarios that was largely unsuspected previously. The phylogenetic coherence between the core genes is sufficient to validate the hypothesis on the evolution of all NCLDV from a common ancestral virus although the set of ancestral genes might be smaller than previously inferred from patterns of gene presence-absence.
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spelling pubmed-34933292012-11-09 Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes Yutin, Natalya Koonin, Eugene V Virol J Research BACKGROUND: The Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) constitute an apparently monophyletic group that consists of at least 6 families of viruses infecting a broad variety of eukaryotic hosts. A comprehensive genome comparison and maximum-likelihood reconstruction of the NCLDV evolution revealed a set of approximately 50 conserved, core genes that could be mapped to the genome of the common ancestor of this class of eukaryotic viruses. RESULTS: We performed a detailed phylogenetic analysis of these core NCLDV genes and applied the constrained tree approach to show that the majority of the core genes are unlikely to be monophyletic. Several of the core genes have been independently acquired from different sources by different NCLDV lineages whereas for the majority of these genes displacement by homologs from cellular organisms in one or more groups of the NCLDV was demonstrated. CONCLUSIONS: A detailed study of the evolution of the genomic core of the NCLDV reveals substantial complexity and diversity of evolutionary scenarios that was largely unsuspected previously. The phylogenetic coherence between the core genes is sufficient to validate the hypothesis on the evolution of all NCLDV from a common ancestral virus although the set of ancestral genes might be smaller than previously inferred from patterns of gene presence-absence. BioMed Central 2012-08-14 /pmc/articles/PMC3493329/ /pubmed/22891861 http://dx.doi.org/10.1186/1743-422X-9-161 Text en Copyright ©2012 Yutin and Koonin; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Yutin, Natalya
Koonin, Eugene V
Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes
title Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes
title_full Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes
title_fullStr Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes
title_full_unstemmed Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes
title_short Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes
title_sort hidden evolutionary complexity of nucleo-cytoplasmic large dna viruses of eukaryotes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493329/
https://www.ncbi.nlm.nih.gov/pubmed/22891861
http://dx.doi.org/10.1186/1743-422X-9-161
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