Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin

BACKGROUND: Influenza A virus non-structural protein 1 (NS1) is a virulence factor, which is targeted into the cell cytoplasm, nucleus and nucleolus. NS1 is a multi-functional protein that inhibits host cell pre-mRNA processing and counteracts host cell antiviral responses. Previously, we have shown...

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Detalles Bibliográficos
Autores principales: Melén, Krister, Tynell, Janne, Fagerlund, Riku, Roussel, Pascal, Hernandez-Verdun, Danièle, Julkunen, Ilkka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493336/
https://www.ncbi.nlm.nih.gov/pubmed/22909121
http://dx.doi.org/10.1186/1743-422X-9-167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493336/
https://www.ncbi.nlm.nih.gov/pubmed/22909121
http://dx.doi.org/10.1186/1743-422X-9-167

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