Cargando…

Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children

BACKGROUND: Currently there are few studies characterising the nature and aetiology of human schistosome-related inflammatory processes. The aim of this study was to determine the relationship between Chitinase 3-like 1 (CHI3L1), also known as YKL-40, a molecule associated with inflammatory processe...

Descripción completa

Detalles Bibliográficos
Autores principales: Appleby, Laura J., Nausch, Norman, Bourke, Claire D., Rujeni, Nadine, Midzi, Nicholas, Mduluza, Takafira, Allen, Judith E., Mutapi, Francisca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493395/
https://www.ncbi.nlm.nih.gov/pubmed/23145202
http://dx.doi.org/10.1371/journal.pntd.0001898
_version_ 1782249259658117120
author Appleby, Laura J.
Nausch, Norman
Bourke, Claire D.
Rujeni, Nadine
Midzi, Nicholas
Mduluza, Takafira
Allen, Judith E.
Mutapi, Francisca
author_facet Appleby, Laura J.
Nausch, Norman
Bourke, Claire D.
Rujeni, Nadine
Midzi, Nicholas
Mduluza, Takafira
Allen, Judith E.
Mutapi, Francisca
author_sort Appleby, Laura J.
collection PubMed
description BACKGROUND: Currently there are few studies characterising the nature and aetiology of human schistosome-related inflammatory processes. The aim of this study was to determine the relationship between Chitinase 3-like 1 (CHI3L1), also known as YKL-40, a molecule associated with inflammatory processes, and schistosome infection, morbidity and systemic cytokine levels. METHODS: Serological levels of CHI3L1 and a panel of cytokines (IFN-y, IL-4/5/6/9/10/13 and 17) were measured in two Zimbabwean populations resident in a high and low schistosome infection area. CHI3L1 levels were related to schistosome infection, haematuria status and cytokine levels after allowing for confounding variables. The effect of antihelminthic treatment with praziquantel on CHI3L1 levels was determined in 246 participants 6 weeks post-treatment. RESULTS: CHI3L1 levels increased with age in both areas but were significantly higher in the high infection areas compared to the low infection area. CHI3L1 levels were also higher in infected compared to uninfected individuals with this difference being significant in the youngest age group. Curative antihelminthic treatment resulted in a significant decrease in CHI3L1 levels. Of the cytokines, only IL-10 and IL-17 had a significant association with CHI3L1 levels, and this association was negative. CONCLUSIONS: Serum CHI3L1 levels differ between infected and uninfected people before and after antihelminthic treatment. The greatest difference occurs in the youngest age group, in keeping with the period when schistosome-related pathological processes are initiated. Following from previous studies in non-infectious diseases showing that CHI3L1 is a biomarker for the inflammatory process, this study suggests that the potential for CHI3L1 as a biomarker for schistosome-related pathology should be explored further.
format Online
Article
Text
id pubmed-3493395
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-34933952012-11-09 Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children Appleby, Laura J. Nausch, Norman Bourke, Claire D. Rujeni, Nadine Midzi, Nicholas Mduluza, Takafira Allen, Judith E. Mutapi, Francisca PLoS Negl Trop Dis Research Article BACKGROUND: Currently there are few studies characterising the nature and aetiology of human schistosome-related inflammatory processes. The aim of this study was to determine the relationship between Chitinase 3-like 1 (CHI3L1), also known as YKL-40, a molecule associated with inflammatory processes, and schistosome infection, morbidity and systemic cytokine levels. METHODS: Serological levels of CHI3L1 and a panel of cytokines (IFN-y, IL-4/5/6/9/10/13 and 17) were measured in two Zimbabwean populations resident in a high and low schistosome infection area. CHI3L1 levels were related to schistosome infection, haematuria status and cytokine levels after allowing for confounding variables. The effect of antihelminthic treatment with praziquantel on CHI3L1 levels was determined in 246 participants 6 weeks post-treatment. RESULTS: CHI3L1 levels increased with age in both areas but were significantly higher in the high infection areas compared to the low infection area. CHI3L1 levels were also higher in infected compared to uninfected individuals with this difference being significant in the youngest age group. Curative antihelminthic treatment resulted in a significant decrease in CHI3L1 levels. Of the cytokines, only IL-10 and IL-17 had a significant association with CHI3L1 levels, and this association was negative. CONCLUSIONS: Serum CHI3L1 levels differ between infected and uninfected people before and after antihelminthic treatment. The greatest difference occurs in the youngest age group, in keeping with the period when schistosome-related pathological processes are initiated. Following from previous studies in non-infectious diseases showing that CHI3L1 is a biomarker for the inflammatory process, this study suggests that the potential for CHI3L1 as a biomarker for schistosome-related pathology should be explored further. Public Library of Science 2012-11-08 /pmc/articles/PMC3493395/ /pubmed/23145202 http://dx.doi.org/10.1371/journal.pntd.0001898 Text en © 2012 Appleby et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Appleby, Laura J.
Nausch, Norman
Bourke, Claire D.
Rujeni, Nadine
Midzi, Nicholas
Mduluza, Takafira
Allen, Judith E.
Mutapi, Francisca
Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
title Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
title_full Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
title_fullStr Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
title_full_unstemmed Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
title_short Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
title_sort chitinase 3-like 1 protein levels are elevated in schistosoma haematobium infected children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493395/
https://www.ncbi.nlm.nih.gov/pubmed/23145202
http://dx.doi.org/10.1371/journal.pntd.0001898
work_keys_str_mv AT applebylauraj chitinase3like1proteinlevelsareelevatedinschistosomahaematobiuminfectedchildren
AT nauschnorman chitinase3like1proteinlevelsareelevatedinschistosomahaematobiuminfectedchildren
AT bourkeclaired chitinase3like1proteinlevelsareelevatedinschistosomahaematobiuminfectedchildren
AT rujeninadine chitinase3like1proteinlevelsareelevatedinschistosomahaematobiuminfectedchildren
AT midzinicholas chitinase3like1proteinlevelsareelevatedinschistosomahaematobiuminfectedchildren
AT mduluzatakafira chitinase3like1proteinlevelsareelevatedinschistosomahaematobiuminfectedchildren
AT allenjudithe chitinase3like1proteinlevelsareelevatedinschistosomahaematobiuminfectedchildren
AT mutapifrancisca chitinase3like1proteinlevelsareelevatedinschistosomahaematobiuminfectedchildren