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Nucleoporins Nup160 and Seh1 are required for disease resistance in Arabidopsis

Arabidopsis Nup160 and Seh1, encoding two predicted nucleoporins of the Nup107–160 nuclear pore sub-complex, were identified in a reverse genetics screen based on their requirement for basal disease resistance. Both genes also contribute to immunity conferred by Toll interleukin 1 receptor/nucleotid...

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Detalles Bibliográficos
Autores principales: Roth, Charlotte, Wiermer, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493398/
https://www.ncbi.nlm.nih.gov/pubmed/22902705
http://dx.doi.org/10.4161/psb.21426
Descripción
Sumario:Arabidopsis Nup160 and Seh1, encoding two predicted nucleoporins of the Nup107–160 nuclear pore sub-complex, were identified in a reverse genetics screen based on their requirement for basal disease resistance. Both genes also contribute to immunity conferred by Toll interleukin 1 receptor/nucleotide-binding/leucine-rich repeat (TNL)-type R proteins and constitutive resistance activated in the deregulated TNL mutant, snc1. Protein amounts of EDS1, a central regulator of TNL-triggered resistance, are reduced in seh1 and severely depleted in nup160 single mutants. Here, we investigate the impact of mutations in Nup160, Seh1 and a third complex member, MOS3/Nup96, on EDS1 protein accumulation in the snc1 auto-immune mutant background. In addition, we examine the subcellular localization of Seh1 in root tissues.