Early Mechanisms of Pathobiology Are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice

Prion diseases typically have long pre-clinical incubation periods during which time the infectious prion particle and infectivity steadily propagate in the brain. Abnormal neuritic sprouting and synaptic deficits are apparent during pre-clinical disease, however, gross neuronal loss is not detected...

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Detalles Bibliográficos
Autores principales: Majer, Anna, Medina, Sarah J., Niu, Yulian, Abrenica, Bernard, Manguiat, Kathy J., Frost, Kathy L., Philipson, Clark S., Sorensen, Debra L., Booth, Stephanie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493483/
https://www.ncbi.nlm.nih.gov/pubmed/23144617
http://dx.doi.org/10.1371/journal.ppat.1003002

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