Cargando…

Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development

Inflammatory conditions may promote tumor progression and aggressiveness. In previous reports, we found a group of breast cancer tumors characterized by metalloprotease-11 (MMP-11) expression by intratumoral mononuclear inflammatory cells (MICs), which was associated with distant metastasis developm...

Descripción completa

Detalles Bibliográficos
Autores principales: Eiró, Noemí, González, Lucía, González, Luis O., Fernandez-Garcia, Belen, Lamelas, Maria Luz, Marín, Laura, González-Reyes, Salomé, del Casar, José Manuel, Vizoso, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493514/
https://www.ncbi.nlm.nih.gov/pubmed/23145063
http://dx.doi.org/10.1371/journal.pone.0049047
_version_ 1782249276962766848
author Eiró, Noemí
González, Lucía
González, Luis O.
Fernandez-Garcia, Belen
Lamelas, Maria Luz
Marín, Laura
González-Reyes, Salomé
del Casar, José Manuel
Vizoso, Francisco J.
author_facet Eiró, Noemí
González, Lucía
González, Luis O.
Fernandez-Garcia, Belen
Lamelas, Maria Luz
Marín, Laura
González-Reyes, Salomé
del Casar, José Manuel
Vizoso, Francisco J.
author_sort Eiró, Noemí
collection PubMed
description Inflammatory conditions may promote tumor progression and aggressiveness. In previous reports, we found a group of breast cancer tumors characterized by metalloprotease-11 (MMP-11) expression by intratumoral mononuclear inflammatory cells (MICs), which was associated with distant metastasis development. Thus, in the present study we evaluated the relationship between MMP-11 expression by MICs, distant metastasis development, and a wide panel of inflammatory factors in breast carcinoma. In an initial approach, we analyzed 65 factors associated with tumor progression and inflammation, in a tumor population classified in good or bad prognosis, based on MMP-11 expression by intratumoral MICs. The most differentially expressed factors were then analyzed in a wider tumor population classified according to MMP-11 expression by MICs and also according to metastasis development. These analyses were carried out by Real-time PCR. The results showed that of the 65 starting factors analyzed, those related with MMP-11 expression by MICs were: IL-1, −5, −6, −8, −17, −18, MMP-1, TIMP-1, ADAM-8, −10, −15, −23, ADAMTS-1, −2, −15, Annexin A2, IFNβ, Claudin-3, CCL-3, MyD88, IRAK-4 and NFκB. Of them, factors more differentially expressed between both groups of tumors were IL-1, IL-5, IL-6, IL-17, IFNβ and NFκB. Thereafter, we confirmed in the wider tumor population, that there is a higher expression of those factors in tumors infiltrated by MMP-11 positive MICs. Altogether these results indicate that tumors developing worse prognosis and identified by MMP-11 expression by intratumoral MICs, shows an up-regulation of inflammatory-related genes.
format Online
Article
Text
id pubmed-3493514
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-34935142012-11-09 Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development Eiró, Noemí González, Lucía González, Luis O. Fernandez-Garcia, Belen Lamelas, Maria Luz Marín, Laura González-Reyes, Salomé del Casar, José Manuel Vizoso, Francisco J. PLoS One Research Article Inflammatory conditions may promote tumor progression and aggressiveness. In previous reports, we found a group of breast cancer tumors characterized by metalloprotease-11 (MMP-11) expression by intratumoral mononuclear inflammatory cells (MICs), which was associated with distant metastasis development. Thus, in the present study we evaluated the relationship between MMP-11 expression by MICs, distant metastasis development, and a wide panel of inflammatory factors in breast carcinoma. In an initial approach, we analyzed 65 factors associated with tumor progression and inflammation, in a tumor population classified in good or bad prognosis, based on MMP-11 expression by intratumoral MICs. The most differentially expressed factors were then analyzed in a wider tumor population classified according to MMP-11 expression by MICs and also according to metastasis development. These analyses were carried out by Real-time PCR. The results showed that of the 65 starting factors analyzed, those related with MMP-11 expression by MICs were: IL-1, −5, −6, −8, −17, −18, MMP-1, TIMP-1, ADAM-8, −10, −15, −23, ADAMTS-1, −2, −15, Annexin A2, IFNβ, Claudin-3, CCL-3, MyD88, IRAK-4 and NFκB. Of them, factors more differentially expressed between both groups of tumors were IL-1, IL-5, IL-6, IL-17, IFNβ and NFκB. Thereafter, we confirmed in the wider tumor population, that there is a higher expression of those factors in tumors infiltrated by MMP-11 positive MICs. Altogether these results indicate that tumors developing worse prognosis and identified by MMP-11 expression by intratumoral MICs, shows an up-regulation of inflammatory-related genes. Public Library of Science 2012-11-08 /pmc/articles/PMC3493514/ /pubmed/23145063 http://dx.doi.org/10.1371/journal.pone.0049047 Text en © 2012 Eiró et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Eiró, Noemí
González, Lucía
González, Luis O.
Fernandez-Garcia, Belen
Lamelas, Maria Luz
Marín, Laura
González-Reyes, Salomé
del Casar, José Manuel
Vizoso, Francisco J.
Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development
title Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development
title_full Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development
title_fullStr Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development
title_full_unstemmed Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development
title_short Relationship between the Inflammatory Molecular Profile of Breast Carcinomas and Distant Metastasis Development
title_sort relationship between the inflammatory molecular profile of breast carcinomas and distant metastasis development
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493514/
https://www.ncbi.nlm.nih.gov/pubmed/23145063
http://dx.doi.org/10.1371/journal.pone.0049047
work_keys_str_mv AT eironoemi relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment
AT gonzalezlucia relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment
AT gonzalezluiso relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment
AT fernandezgarciabelen relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment
AT lamelasmarialuz relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment
AT marinlaura relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment
AT gonzalezreyessalome relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment
AT delcasarjosemanuel relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment
AT vizosofranciscoj relationshipbetweentheinflammatorymolecularprofileofbreastcarcinomasanddistantmetastasisdevelopment