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Cell Penetrable Humanized-VH/V(H)H That Inhibit RNA Dependent RNA Polymerase (NS5B) of HCV

NS5B is pivotal RNA dependent RNA polymerase (RdRp) of HCV and NS5B function interfering halts the virus infective cycle. This work aimed to produce cell penetrable humanized single domain antibodies (SdAb; VH/V(H)H) that interfere with the RdRp activity. Recombinant NS5BΔ55 of genotype 3a HCV with...

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Detalles Bibliográficos
Autores principales:	Thueng-in, Kanyarat, Thanongsaksrikul, Jeeraphong, Srimanote, Potjanee, Bangphoomi, Kunan, Poungpair, Ornnuthchar, Maneewatch, Santi, Choowongkomon, Kiattawee, Chaicumpa, Wanpen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493538/ https://www.ncbi.nlm.nih.gov/pubmed/23145135 http://dx.doi.org/10.1371/journal.pone.0049254

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