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Bilayer Elasticity at the Nanoscale: The Need for New Terms

Continuum elastic models that account for membrane thickness variations are especially useful in the description of nanoscale deformations due to the presence of membrane proteins with hydrophobic mismatch. We show that terms involving the gradient and the Laplacian of the area per lipid are signifi...

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Detalles Bibliográficos
Autores principales: Bitbol, Anne-Florence, Constantin, Doru, Fournier, Jean-Baptiste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493577/
https://www.ncbi.nlm.nih.gov/pubmed/23144862
http://dx.doi.org/10.1371/journal.pone.0048306
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author Bitbol, Anne-Florence
Constantin, Doru
Fournier, Jean-Baptiste
author_facet Bitbol, Anne-Florence
Constantin, Doru
Fournier, Jean-Baptiste
author_sort Bitbol, Anne-Florence
collection PubMed
description Continuum elastic models that account for membrane thickness variations are especially useful in the description of nanoscale deformations due to the presence of membrane proteins with hydrophobic mismatch. We show that terms involving the gradient and the Laplacian of the area per lipid are significant and must be retained in the effective Hamiltonian of the membrane. We reanalyze recent numerical data, as well as experimental data on gramicidin channels, in light of our model. This analysis yields consistent results for the term stemming from the gradient of the area per molecule. The order of magnitude we find for the associated amplitude, namely 13–60 mN/m, is in good agreement with the 25 mN/m contribution of the interfacial tension between water and the hydrophobic part of the membrane. The presence of this term explains a systematic variation in previously published numerical data.
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spelling pubmed-34935772012-11-09 Bilayer Elasticity at the Nanoscale: The Need for New Terms Bitbol, Anne-Florence Constantin, Doru Fournier, Jean-Baptiste PLoS One Research Article Continuum elastic models that account for membrane thickness variations are especially useful in the description of nanoscale deformations due to the presence of membrane proteins with hydrophobic mismatch. We show that terms involving the gradient and the Laplacian of the area per lipid are significant and must be retained in the effective Hamiltonian of the membrane. We reanalyze recent numerical data, as well as experimental data on gramicidin channels, in light of our model. This analysis yields consistent results for the term stemming from the gradient of the area per molecule. The order of magnitude we find for the associated amplitude, namely 13–60 mN/m, is in good agreement with the 25 mN/m contribution of the interfacial tension between water and the hydrophobic part of the membrane. The presence of this term explains a systematic variation in previously published numerical data. Public Library of Science 2012-11-08 /pmc/articles/PMC3493577/ /pubmed/23144862 http://dx.doi.org/10.1371/journal.pone.0048306 Text en © 2012 Bitbol et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bitbol, Anne-Florence
Constantin, Doru
Fournier, Jean-Baptiste
Bilayer Elasticity at the Nanoscale: The Need for New Terms
title Bilayer Elasticity at the Nanoscale: The Need for New Terms
title_full Bilayer Elasticity at the Nanoscale: The Need for New Terms
title_fullStr Bilayer Elasticity at the Nanoscale: The Need for New Terms
title_full_unstemmed Bilayer Elasticity at the Nanoscale: The Need for New Terms
title_short Bilayer Elasticity at the Nanoscale: The Need for New Terms
title_sort bilayer elasticity at the nanoscale: the need for new terms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493577/
https://www.ncbi.nlm.nih.gov/pubmed/23144862
http://dx.doi.org/10.1371/journal.pone.0048306
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