Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

Voltage-gated sodium channels are vital membrane proteins essential for electrical signalling; in humans, they are key targets for the development of pharmaceutical drugs. Here we report the crystal structure of an open-channel conformation of NavMs, the bacterial channel pore from the marine bacter...

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Detalles Bibliográficos
Autores principales: McCusker, Emily C., Bagnéris, Claire, Naylor, Claire E., Cole, Ambrose R., D'Avanzo, Nazzareno, Nichols, Colin G., Wallace, B.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493636/
https://www.ncbi.nlm.nih.gov/pubmed/23033078
http://dx.doi.org/10.1038/ncomms2077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493636/
https://www.ncbi.nlm.nih.gov/pubmed/23033078
http://dx.doi.org/10.1038/ncomms2077

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