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Diabetes and breast cancer risk: a meta-analysis
BACKGROUND: The potential of an increased risk of breast cancer in women with diabetes has been the subject of a great deal of recent research. METHODS: A meta-analysis was undertaken using a random effects model to investigate the association between diabetes and breast cancer risk. RESULTS: Thirty...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493760/ https://www.ncbi.nlm.nih.gov/pubmed/22996614 http://dx.doi.org/10.1038/bjc.2012.414 |
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author | Boyle, P Boniol, M Koechlin, A Robertson, C Valentini, F Coppens, K Fairley, L-L Boniol, M Zheng, T Zhang, Y Pasterk, M Smans, M Curado, M P Mullie, P Gandini, S Bota, M Bolli, G B Rosenstock, J Autier, P |
author_facet | Boyle, P Boniol, M Koechlin, A Robertson, C Valentini, F Coppens, K Fairley, L-L Boniol, M Zheng, T Zhang, Y Pasterk, M Smans, M Curado, M P Mullie, P Gandini, S Bota, M Bolli, G B Rosenstock, J Autier, P |
author_sort | Boyle, P |
collection | PubMed |
description | BACKGROUND: The potential of an increased risk of breast cancer in women with diabetes has been the subject of a great deal of recent research. METHODS: A meta-analysis was undertaken using a random effects model to investigate the association between diabetes and breast cancer risk. RESULTS: Thirty-nine independent risk estimates were available from observational epidemiological studies. The summary relative risk (SRR) for breast cancer in women with diabetes was 1.27 (95% confidence interval (CI), 1.16–1.39) with no evidence of publication bias. Prospective studies showed a lower risk (SRR 1.23 (95% CI, 1.12–1.35)) than retrospective studies (SRR 1.36 (95% CI, 1.13–1.63)). Type 1 diabetes, or diabetes in pre-menopausal women, were not associated with risk of breast cancer (SRR 1.00 (95% CI, 0.74–1.35) and SRR 0.86 (95% CI, 0.66–1.12), respectively). Studies adjusting for body mass index (BMI) showed lower estimates (SRR 1.16 (95% CI, 1.08–1.24)) as compared with those studies that were not adjusted for BMI (SRR 1.33 (95% CI, 1.18–1.51)). CONCLUSION: The risk of breast cancer in women with type 2 diabetes is increased by 27%, a figure that decreased to 16% after adjustment for BMI. No increased risk was seen for women at pre-menopausal ages or with type 1 diabetes. |
format | Online Article Text |
id | pubmed-3493760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-34937602013-10-23 Diabetes and breast cancer risk: a meta-analysis Boyle, P Boniol, M Koechlin, A Robertson, C Valentini, F Coppens, K Fairley, L-L Boniol, M Zheng, T Zhang, Y Pasterk, M Smans, M Curado, M P Mullie, P Gandini, S Bota, M Bolli, G B Rosenstock, J Autier, P Br J Cancer Epidemiology BACKGROUND: The potential of an increased risk of breast cancer in women with diabetes has been the subject of a great deal of recent research. METHODS: A meta-analysis was undertaken using a random effects model to investigate the association between diabetes and breast cancer risk. RESULTS: Thirty-nine independent risk estimates were available from observational epidemiological studies. The summary relative risk (SRR) for breast cancer in women with diabetes was 1.27 (95% confidence interval (CI), 1.16–1.39) with no evidence of publication bias. Prospective studies showed a lower risk (SRR 1.23 (95% CI, 1.12–1.35)) than retrospective studies (SRR 1.36 (95% CI, 1.13–1.63)). Type 1 diabetes, or diabetes in pre-menopausal women, were not associated with risk of breast cancer (SRR 1.00 (95% CI, 0.74–1.35) and SRR 0.86 (95% CI, 0.66–1.12), respectively). Studies adjusting for body mass index (BMI) showed lower estimates (SRR 1.16 (95% CI, 1.08–1.24)) as compared with those studies that were not adjusted for BMI (SRR 1.33 (95% CI, 1.18–1.51)). CONCLUSION: The risk of breast cancer in women with type 2 diabetes is increased by 27%, a figure that decreased to 16% after adjustment for BMI. No increased risk was seen for women at pre-menopausal ages or with type 1 diabetes. Nature Publishing Group 2012-10-23 2012-09-20 /pmc/articles/PMC3493760/ /pubmed/22996614 http://dx.doi.org/10.1038/bjc.2012.414 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by-nc-sa/3.0/From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Epidemiology Boyle, P Boniol, M Koechlin, A Robertson, C Valentini, F Coppens, K Fairley, L-L Boniol, M Zheng, T Zhang, Y Pasterk, M Smans, M Curado, M P Mullie, P Gandini, S Bota, M Bolli, G B Rosenstock, J Autier, P Diabetes and breast cancer risk: a meta-analysis |
title | Diabetes and breast cancer risk: a meta-analysis |
title_full | Diabetes and breast cancer risk: a meta-analysis |
title_fullStr | Diabetes and breast cancer risk: a meta-analysis |
title_full_unstemmed | Diabetes and breast cancer risk: a meta-analysis |
title_short | Diabetes and breast cancer risk: a meta-analysis |
title_sort | diabetes and breast cancer risk: a meta-analysis |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493760/ https://www.ncbi.nlm.nih.gov/pubmed/22996614 http://dx.doi.org/10.1038/bjc.2012.414 |
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