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Diabetes and breast cancer risk: a meta-analysis

BACKGROUND: The potential of an increased risk of breast cancer in women with diabetes has been the subject of a great deal of recent research. METHODS: A meta-analysis was undertaken using a random effects model to investigate the association between diabetes and breast cancer risk. RESULTS: Thirty...

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Autores principales: Boyle, P, Boniol, M, Koechlin, A, Robertson, C, Valentini, F, Coppens, K, Fairley, L-L, Zheng, T, Zhang, Y, Pasterk, M, Smans, M, Curado, M P, Mullie, P, Gandini, S, Bota, M, Bolli, G B, Rosenstock, J, Autier, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493760/
https://www.ncbi.nlm.nih.gov/pubmed/22996614
http://dx.doi.org/10.1038/bjc.2012.414
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author Boyle, P
Boniol, M
Koechlin, A
Robertson, C
Valentini, F
Coppens, K
Fairley, L-L
Boniol, M
Zheng, T
Zhang, Y
Pasterk, M
Smans, M
Curado, M P
Mullie, P
Gandini, S
Bota, M
Bolli, G B
Rosenstock, J
Autier, P
author_facet Boyle, P
Boniol, M
Koechlin, A
Robertson, C
Valentini, F
Coppens, K
Fairley, L-L
Boniol, M
Zheng, T
Zhang, Y
Pasterk, M
Smans, M
Curado, M P
Mullie, P
Gandini, S
Bota, M
Bolli, G B
Rosenstock, J
Autier, P
author_sort Boyle, P
collection PubMed
description BACKGROUND: The potential of an increased risk of breast cancer in women with diabetes has been the subject of a great deal of recent research. METHODS: A meta-analysis was undertaken using a random effects model to investigate the association between diabetes and breast cancer risk. RESULTS: Thirty-nine independent risk estimates were available from observational epidemiological studies. The summary relative risk (SRR) for breast cancer in women with diabetes was 1.27 (95% confidence interval (CI), 1.16–1.39) with no evidence of publication bias. Prospective studies showed a lower risk (SRR 1.23 (95% CI, 1.12–1.35)) than retrospective studies (SRR 1.36 (95% CI, 1.13–1.63)). Type 1 diabetes, or diabetes in pre-menopausal women, were not associated with risk of breast cancer (SRR 1.00 (95% CI, 0.74–1.35) and SRR 0.86 (95% CI, 0.66–1.12), respectively). Studies adjusting for body mass index (BMI) showed lower estimates (SRR 1.16 (95% CI, 1.08–1.24)) as compared with those studies that were not adjusted for BMI (SRR 1.33 (95% CI, 1.18–1.51)). CONCLUSION: The risk of breast cancer in women with type 2 diabetes is increased by 27%, a figure that decreased to 16% after adjustment for BMI. No increased risk was seen for women at pre-menopausal ages or with type 1 diabetes.
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spelling pubmed-34937602013-10-23 Diabetes and breast cancer risk: a meta-analysis Boyle, P Boniol, M Koechlin, A Robertson, C Valentini, F Coppens, K Fairley, L-L Boniol, M Zheng, T Zhang, Y Pasterk, M Smans, M Curado, M P Mullie, P Gandini, S Bota, M Bolli, G B Rosenstock, J Autier, P Br J Cancer Epidemiology BACKGROUND: The potential of an increased risk of breast cancer in women with diabetes has been the subject of a great deal of recent research. METHODS: A meta-analysis was undertaken using a random effects model to investigate the association between diabetes and breast cancer risk. RESULTS: Thirty-nine independent risk estimates were available from observational epidemiological studies. The summary relative risk (SRR) for breast cancer in women with diabetes was 1.27 (95% confidence interval (CI), 1.16–1.39) with no evidence of publication bias. Prospective studies showed a lower risk (SRR 1.23 (95% CI, 1.12–1.35)) than retrospective studies (SRR 1.36 (95% CI, 1.13–1.63)). Type 1 diabetes, or diabetes in pre-menopausal women, were not associated with risk of breast cancer (SRR 1.00 (95% CI, 0.74–1.35) and SRR 0.86 (95% CI, 0.66–1.12), respectively). Studies adjusting for body mass index (BMI) showed lower estimates (SRR 1.16 (95% CI, 1.08–1.24)) as compared with those studies that were not adjusted for BMI (SRR 1.33 (95% CI, 1.18–1.51)). CONCLUSION: The risk of breast cancer in women with type 2 diabetes is increased by 27%, a figure that decreased to 16% after adjustment for BMI. No increased risk was seen for women at pre-menopausal ages or with type 1 diabetes. Nature Publishing Group 2012-10-23 2012-09-20 /pmc/articles/PMC3493760/ /pubmed/22996614 http://dx.doi.org/10.1038/bjc.2012.414 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by-nc-sa/3.0/From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Boyle, P
Boniol, M
Koechlin, A
Robertson, C
Valentini, F
Coppens, K
Fairley, L-L
Boniol, M
Zheng, T
Zhang, Y
Pasterk, M
Smans, M
Curado, M P
Mullie, P
Gandini, S
Bota, M
Bolli, G B
Rosenstock, J
Autier, P
Diabetes and breast cancer risk: a meta-analysis
title Diabetes and breast cancer risk: a meta-analysis
title_full Diabetes and breast cancer risk: a meta-analysis
title_fullStr Diabetes and breast cancer risk: a meta-analysis
title_full_unstemmed Diabetes and breast cancer risk: a meta-analysis
title_short Diabetes and breast cancer risk: a meta-analysis
title_sort diabetes and breast cancer risk: a meta-analysis
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493760/
https://www.ncbi.nlm.nih.gov/pubmed/22996614
http://dx.doi.org/10.1038/bjc.2012.414
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