Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

Live attenuated SIV vaccines (LAVs) remain the most efficacious of all vaccines in nonhuman primate (NHP) models of HIV/AIDS, yet the basis of their robust protection remains poorly understood. Here, we demonstrate that the degree of LAV-mediated protection against intravenous wildtype SIVmac239 cha...

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Detalles Bibliográficos
Autores principales: Fukazawa, Yoshinori, Park, Haesun, Cameron, Mark J., Lefebvre, Francois, Lum, Richard, Coombes, Noel, Mahyari, Eisa, Hagen, Shoko, Bae, Jin Young, Reyes, Marcelo Delos, Swanson, Tonya, Legasse, Alfred W., Sylwester, Andrew, Hansen, Scott G., Smith, Andrew T., Stafova, Petra, Shoemaker, Rebecca, Li, Yuan, Oswald, Kelli, Axthelm, Michael K., McDermott, Adrian, Ferrari, Guido, Montefiori, David C., Edlefsen, Paul T., Piatak, Michael, Lifson, Jeffrey D., Sékaly, Rafick P., Picker, Louis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493820/
https://www.ncbi.nlm.nih.gov/pubmed/22961108
http://dx.doi.org/10.1038/nm.2934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493820/
https://www.ncbi.nlm.nih.gov/pubmed/22961108
http://dx.doi.org/10.1038/nm.2934

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