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Case–control study of markers of insulin resistance and endometrial cancer risk

Markers of insulin resistance such as the adiponectin:leptin ratio (A:L) and the homeostasis model assessment ratio (HOMA-IR) are associated with obesity and hyperinsulinemia, both established risk factors for endometrial cancer, and may therefore be informative regarding endometrial cancer risk. Th...

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Autores principales: Friedenreich, Christine M, Langley, Annie R, Speidel, Thomas P, Lau, David C W, Courneya, Kerry S, Csizmadi, Ilona, Magliocco, Anthony M, Yasui, Yutaka, Cook, Linda S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Endocrinology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493985/
https://www.ncbi.nlm.nih.gov/pubmed/23033315
http://dx.doi.org/10.1530/ERC-12-0211
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author Friedenreich, Christine M
Langley, Annie R
Speidel, Thomas P
Lau, David C W
Courneya, Kerry S
Csizmadi, Ilona
Magliocco, Anthony M
Yasui, Yutaka
Cook, Linda S
author_facet Friedenreich, Christine M
Langley, Annie R
Speidel, Thomas P
Lau, David C W
Courneya, Kerry S
Csizmadi, Ilona
Magliocco, Anthony M
Yasui, Yutaka
Cook, Linda S
author_sort Friedenreich, Christine M
collection PubMed
description Markers of insulin resistance such as the adiponectin:leptin ratio (A:L) and the homeostasis model assessment ratio (HOMA-IR) are associated with obesity and hyperinsulinemia, both established risk factors for endometrial cancer, and may therefore be informative regarding endometrial cancer risk. This study investigated the association between endometrial cancer risk and markers of insulin resistance, namely adiponectin, leptin, the A:L ratio, insulin, fasting glucose, and the HOMA-IR. We analyzed data from 541 incident endometrial cancer cases and 961 frequency age-matched controls in a population-based case–control study in Alberta, Canada from 2002 to 2006. Participants completed interview-administered questionnaires were assessed for anthropometric measures, and provided 8-h fasting blood samples either pre- or postoperatively. Blood was analyzed for concentrations of leptin, adiponectin, and insulin by immunoassay, and fasting plasma glucose levels were determined by fluorimetric quantitative determination. Compared with the lowest quartile, the highest quartile of insulin and HOMA-IR was associated with 64% (95% confidence intervals (CI): 1.12–2.40) and 72% (95% CI: 1.17–2.53) increased risks of endometrial cancer, respectively, and the highest quartile of adiponectin was associated with a 45% (95% CI: 0.37–0.80) decreased risk after multivariable adjustments. Null associations were observed between fasting glucose, leptin and A:L, and endometrial cancer risk. This population-based study provides evidence for a role of insulin resistance in endometrial cancer etiology and may provide one possible pathway whereby obesity increases the risk of this common cancer. Interventions aimed at decreasing both obesity and insulin resistance may decrease endometrial cancer risk.
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spelling pubmed-34939852012-12-01 Case–control study of markers of insulin resistance and endometrial cancer risk Friedenreich, Christine M Langley, Annie R Speidel, Thomas P Lau, David C W Courneya, Kerry S Csizmadi, Ilona Magliocco, Anthony M Yasui, Yutaka Cook, Linda S Endocr Relat Cancer Regular Papers Markers of insulin resistance such as the adiponectin:leptin ratio (A:L) and the homeostasis model assessment ratio (HOMA-IR) are associated with obesity and hyperinsulinemia, both established risk factors for endometrial cancer, and may therefore be informative regarding endometrial cancer risk. This study investigated the association between endometrial cancer risk and markers of insulin resistance, namely adiponectin, leptin, the A:L ratio, insulin, fasting glucose, and the HOMA-IR. We analyzed data from 541 incident endometrial cancer cases and 961 frequency age-matched controls in a population-based case–control study in Alberta, Canada from 2002 to 2006. Participants completed interview-administered questionnaires were assessed for anthropometric measures, and provided 8-h fasting blood samples either pre- or postoperatively. Blood was analyzed for concentrations of leptin, adiponectin, and insulin by immunoassay, and fasting plasma glucose levels were determined by fluorimetric quantitative determination. Compared with the lowest quartile, the highest quartile of insulin and HOMA-IR was associated with 64% (95% confidence intervals (CI): 1.12–2.40) and 72% (95% CI: 1.17–2.53) increased risks of endometrial cancer, respectively, and the highest quartile of adiponectin was associated with a 45% (95% CI: 0.37–0.80) decreased risk after multivariable adjustments. Null associations were observed between fasting glucose, leptin and A:L, and endometrial cancer risk. This population-based study provides evidence for a role of insulin resistance in endometrial cancer etiology and may provide one possible pathway whereby obesity increases the risk of this common cancer. Interventions aimed at decreasing both obesity and insulin resistance may decrease endometrial cancer risk. Society for Endocrinology 2012-12 /pmc/articles/PMC3493985/ /pubmed/23033315 http://dx.doi.org/10.1530/ERC-12-0211 Text en © 2012 Society for Endocrinology http://www.endocrinology.org/journals/reuselicence/ This is an Open Access article distributed under the terms of the Society for Endocrinology's Re-use Licence (http://www.endocrinology.org/journals/reuselicence/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Papers
Friedenreich, Christine M
Langley, Annie R
Speidel, Thomas P
Lau, David C W
Courneya, Kerry S
Csizmadi, Ilona
Magliocco, Anthony M
Yasui, Yutaka
Cook, Linda S
Case–control study of markers of insulin resistance and endometrial cancer risk
title Case–control study of markers of insulin resistance and endometrial cancer risk
title_full Case–control study of markers of insulin resistance and endometrial cancer risk
title_fullStr Case–control study of markers of insulin resistance and endometrial cancer risk
title_full_unstemmed Case–control study of markers of insulin resistance and endometrial cancer risk
title_short Case–control study of markers of insulin resistance and endometrial cancer risk
title_sort case–control study of markers of insulin resistance and endometrial cancer risk
topic Regular Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493985/
https://www.ncbi.nlm.nih.gov/pubmed/23033315
http://dx.doi.org/10.1530/ERC-12-0211
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