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Case–control study of markers of insulin resistance and endometrial cancer risk
Markers of insulin resistance such as the adiponectin:leptin ratio (A:L) and the homeostasis model assessment ratio (HOMA-IR) are associated with obesity and hyperinsulinemia, both established risk factors for endometrial cancer, and may therefore be informative regarding endometrial cancer risk. Th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Endocrinology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493985/ https://www.ncbi.nlm.nih.gov/pubmed/23033315 http://dx.doi.org/10.1530/ERC-12-0211 |
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author | Friedenreich, Christine M Langley, Annie R Speidel, Thomas P Lau, David C W Courneya, Kerry S Csizmadi, Ilona Magliocco, Anthony M Yasui, Yutaka Cook, Linda S |
author_facet | Friedenreich, Christine M Langley, Annie R Speidel, Thomas P Lau, David C W Courneya, Kerry S Csizmadi, Ilona Magliocco, Anthony M Yasui, Yutaka Cook, Linda S |
author_sort | Friedenreich, Christine M |
collection | PubMed |
description | Markers of insulin resistance such as the adiponectin:leptin ratio (A:L) and the homeostasis model assessment ratio (HOMA-IR) are associated with obesity and hyperinsulinemia, both established risk factors for endometrial cancer, and may therefore be informative regarding endometrial cancer risk. This study investigated the association between endometrial cancer risk and markers of insulin resistance, namely adiponectin, leptin, the A:L ratio, insulin, fasting glucose, and the HOMA-IR. We analyzed data from 541 incident endometrial cancer cases and 961 frequency age-matched controls in a population-based case–control study in Alberta, Canada from 2002 to 2006. Participants completed interview-administered questionnaires were assessed for anthropometric measures, and provided 8-h fasting blood samples either pre- or postoperatively. Blood was analyzed for concentrations of leptin, adiponectin, and insulin by immunoassay, and fasting plasma glucose levels were determined by fluorimetric quantitative determination. Compared with the lowest quartile, the highest quartile of insulin and HOMA-IR was associated with 64% (95% confidence intervals (CI): 1.12–2.40) and 72% (95% CI: 1.17–2.53) increased risks of endometrial cancer, respectively, and the highest quartile of adiponectin was associated with a 45% (95% CI: 0.37–0.80) decreased risk after multivariable adjustments. Null associations were observed between fasting glucose, leptin and A:L, and endometrial cancer risk. This population-based study provides evidence for a role of insulin resistance in endometrial cancer etiology and may provide one possible pathway whereby obesity increases the risk of this common cancer. Interventions aimed at decreasing both obesity and insulin resistance may decrease endometrial cancer risk. |
format | Online Article Text |
id | pubmed-3493985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Society for Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-34939852012-12-01 Case–control study of markers of insulin resistance and endometrial cancer risk Friedenreich, Christine M Langley, Annie R Speidel, Thomas P Lau, David C W Courneya, Kerry S Csizmadi, Ilona Magliocco, Anthony M Yasui, Yutaka Cook, Linda S Endocr Relat Cancer Regular Papers Markers of insulin resistance such as the adiponectin:leptin ratio (A:L) and the homeostasis model assessment ratio (HOMA-IR) are associated with obesity and hyperinsulinemia, both established risk factors for endometrial cancer, and may therefore be informative regarding endometrial cancer risk. This study investigated the association between endometrial cancer risk and markers of insulin resistance, namely adiponectin, leptin, the A:L ratio, insulin, fasting glucose, and the HOMA-IR. We analyzed data from 541 incident endometrial cancer cases and 961 frequency age-matched controls in a population-based case–control study in Alberta, Canada from 2002 to 2006. Participants completed interview-administered questionnaires were assessed for anthropometric measures, and provided 8-h fasting blood samples either pre- or postoperatively. Blood was analyzed for concentrations of leptin, adiponectin, and insulin by immunoassay, and fasting plasma glucose levels were determined by fluorimetric quantitative determination. Compared with the lowest quartile, the highest quartile of insulin and HOMA-IR was associated with 64% (95% confidence intervals (CI): 1.12–2.40) and 72% (95% CI: 1.17–2.53) increased risks of endometrial cancer, respectively, and the highest quartile of adiponectin was associated with a 45% (95% CI: 0.37–0.80) decreased risk after multivariable adjustments. Null associations were observed between fasting glucose, leptin and A:L, and endometrial cancer risk. This population-based study provides evidence for a role of insulin resistance in endometrial cancer etiology and may provide one possible pathway whereby obesity increases the risk of this common cancer. Interventions aimed at decreasing both obesity and insulin resistance may decrease endometrial cancer risk. Society for Endocrinology 2012-12 /pmc/articles/PMC3493985/ /pubmed/23033315 http://dx.doi.org/10.1530/ERC-12-0211 Text en © 2012 Society for Endocrinology http://www.endocrinology.org/journals/reuselicence/ This is an Open Access article distributed under the terms of the Society for Endocrinology's Re-use Licence (http://www.endocrinology.org/journals/reuselicence/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Papers Friedenreich, Christine M Langley, Annie R Speidel, Thomas P Lau, David C W Courneya, Kerry S Csizmadi, Ilona Magliocco, Anthony M Yasui, Yutaka Cook, Linda S Case–control study of markers of insulin resistance and endometrial cancer risk |
title | Case–control study of markers of insulin resistance and endometrial cancer risk |
title_full | Case–control study of markers of insulin resistance and endometrial cancer risk |
title_fullStr | Case–control study of markers of insulin resistance and endometrial cancer risk |
title_full_unstemmed | Case–control study of markers of insulin resistance and endometrial cancer risk |
title_short | Case–control study of markers of insulin resistance and endometrial cancer risk |
title_sort | case–control study of markers of insulin resistance and endometrial cancer risk |
topic | Regular Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493985/ https://www.ncbi.nlm.nih.gov/pubmed/23033315 http://dx.doi.org/10.1530/ERC-12-0211 |
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