Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such errors and the underlying mechanism in sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired exon exclusions and selective loss of the hnRNP A/B sp...

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Detalles Bibliográficos
Autores principales: Berson, Amit, Barbash, Shahar, Shaltiel, Galit, Goll, Yael, Hanin, Geula, Greenberg, David S, Ketzef, Maya, Becker, Albert J, Friedman, Alon, Soreq, Hermona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494073/
https://www.ncbi.nlm.nih.gov/pubmed/22628224
http://dx.doi.org/10.1002/emmm.201100995

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