Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome

BACKGROUND: Using mRNA expression-derived signatures as predictors of individual patient outcome has been a goal ever since the introduction of microarrays. Here, we addressed whether analyses of tumour mRNA at the exon level can improve on the predictive power and classification accuracy of gene-ba...

Descripción completa

Detalles Bibliográficos
Autores principales: Schramm, A, Schowe, B, Fielitz, K, Heilmann, M, Martin, M, Marschall, T, Köster, J, Vandesompele, J, Vermeulen, J, de Preter, K, Koster, J, Versteeg, R, Noguera, R, Speleman, F, Rahmann, S, Eggert, A, Morik, K, Schulte, J H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494449/
https://www.ncbi.nlm.nih.gov/pubmed/23047593
http://dx.doi.org/10.1038/bjc.2012.391

Ejemplares similares

Ejemplares similares