Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy

BACKGROUND: Cell death induced by poly(ADP-ribose) (PAR) and mediated by apoptosis-inducing factor (AIF) is well-characterized in models of ischemic tissue injury, but their roles in cancer cell death after chemotherapy are less understood. METHODS: Here we investigated the roles of PAR and AIF by R...

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Detalles Bibliográficos
Autores principales: Feng, Xiaoxing, Zhou, Yiran, Proctor, Alicia M, Hopkins, Mandi M, Liu, Mengwei, Koh, David W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494550/
https://www.ncbi.nlm.nih.gov/pubmed/22839996
http://dx.doi.org/10.1186/1476-4598-11-48

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