A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria

The electronic records of 398 patients with chronic spontaneous urticaria (CSU) who had had a serum basophil histamine release assay (BHRA) performed as a marker of functional autoantibodies were audited. The BHRA was positive in 105 patients (26.4%). Fifty eight were treated with ciclosporin becaus...

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Autores principales: Iqbal, Kamran, Bhargava, Kapil, Skov, Per Stahl, Falkencrone, Sidsel, Grattan, Clive EH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494608/
https://www.ncbi.nlm.nih.gov/pubmed/23025508
http://dx.doi.org/10.1186/2045-7022-2-19
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author Iqbal, Kamran
Bhargava, Kapil
Skov, Per Stahl
Falkencrone, Sidsel
Grattan, Clive EH
author_facet Iqbal, Kamran
Bhargava, Kapil
Skov, Per Stahl
Falkencrone, Sidsel
Grattan, Clive EH
author_sort Iqbal, Kamran
collection PubMed
description The electronic records of 398 patients with chronic spontaneous urticaria (CSU) who had had a serum basophil histamine release assay (BHRA) performed as a marker of functional autoantibodies were audited. The BHRA was positive in 105 patients (26.4%). Fifty eight were treated with ciclosporin because they were H1 anti-histamine unresponsive. CSU patients with a positive BHRA were more likely to respond clinically (P<0.001) and to have raised thyroid autoantibodies (P<0.02) than those with a negative BHRA. The BHRA offers a useful predictive biomarker for a good response of H1 antihistamine-unresponsive CSU patients to ciclosporin.
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spelling pubmed-34946082012-11-10 A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria Iqbal, Kamran Bhargava, Kapil Skov, Per Stahl Falkencrone, Sidsel Grattan, Clive EH Clin Transl Allergy Brief Communication The electronic records of 398 patients with chronic spontaneous urticaria (CSU) who had had a serum basophil histamine release assay (BHRA) performed as a marker of functional autoantibodies were audited. The BHRA was positive in 105 patients (26.4%). Fifty eight were treated with ciclosporin because they were H1 anti-histamine unresponsive. CSU patients with a positive BHRA were more likely to respond clinically (P<0.001) and to have raised thyroid autoantibodies (P<0.02) than those with a negative BHRA. The BHRA offers a useful predictive biomarker for a good response of H1 antihistamine-unresponsive CSU patients to ciclosporin. BioMed Central 2012-10-01 /pmc/articles/PMC3494608/ /pubmed/23025508 http://dx.doi.org/10.1186/2045-7022-2-19 Text en Copyright ©2012 Iqbal et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Iqbal, Kamran
Bhargava, Kapil
Skov, Per Stahl
Falkencrone, Sidsel
Grattan, Clive EH
A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria
title A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria
title_full A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria
title_fullStr A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria
title_full_unstemmed A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria
title_short A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria
title_sort positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494608/
https://www.ncbi.nlm.nih.gov/pubmed/23025508
http://dx.doi.org/10.1186/2045-7022-2-19
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