Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

Mice with an impaired Type I interferon (IFN) signaling (IFNAR1- and IFNβ-deficient mice) display an increased susceptibility toward v-ABL-induced B-cell leukemia/lymphoma. The enhanced leukemogenesis in the absence of an intact Type I IFN signaling is caused by alterations within the tumor environm...

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Detalles Bibliográficos
Autores principales: Mizutani, Tatsuaki, Neugebauer, Nina, Putz, Eva M., Moritz, Nadine, Simma, Olivia, Zebedin-Brandl, Eva, Gotthardt, Dagmar, Warsch, Wolfgang, Eckelhart, Eva, Kantner, Hans-Peter, Kalinke, Ulrich, Lienenklaus, Stefan, Weiss, Siegfried, Strobl, Birgit, Müller, Mathias, Sexl, Veronika, Stoiber, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494617/
https://www.ncbi.nlm.nih.gov/pubmed/23170251
http://dx.doi.org/10.4161/onci.21284

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