Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo

Overexpression of HER-2 and VEGF plays a key role in the development and metastasis of several human cancers. Many FDA-approved therapies targeting both HER-2 (Trastuzumab, Herceptin) and VEGF (Bevacizumab, Avastin) are expensive, have unacceptable toxicities and are often associated with the develo...

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Detalles Bibliográficos
Autores principales: Foy, Kevin C., Miller, Megan J., Moldovan, Nicanor, Carson, William E., Kaumaya, Pravin T. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494619/
https://www.ncbi.nlm.nih.gov/pubmed/23170253
http://dx.doi.org/10.4161/onci.20708

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