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B7-H1 limits the entry of effector CD8(+) T cells to the memory pool by upregulating Bim

Protective T‑cell immunity against cancer and infections is dependent on the generation of a durable effector and memory T‑cell pool. Studies from cancer and chronic infections reveal that B7-H1 (PD-L1) engagement with its receptor PD-1 promotes apoptosis of effector T cells. It is not clear how B7-...

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Detalles Bibliográficos
Autores principales:	Gibbons, Rachel M., Liu, Xin, Pulko, Vesna, Harrington, Susan M., Krco, Christopher J., Kwon, Eugene D., Dong, Haidong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494620/ https://www.ncbi.nlm.nih.gov/pubmed/23170254 http://dx.doi.org/10.4161/onci.20850

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