Friend or foe: A novel role of β-defensins in tumor development

For many years, β-defensins were best known for their antimicrobial activity. However, β-defensins also exert immunomodulatory functions, such as the chemotactic recruitment of immune cells via chemokine receptors. We demonstrated that mouse β-defensin 14 recruits CCR6(+) B cells into fibrosarcomas,...

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Detalles Bibliográficos
Autores principales: Röhrl, Johann, Geissler, Edward K., Hehlgans, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494629/
https://www.ncbi.nlm.nih.gov/pubmed/23170263
http://dx.doi.org/10.4161/onci.20825
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author Röhrl, Johann
Geissler, Edward K.
Hehlgans, Thomas
author_facet Röhrl, Johann
Geissler, Edward K.
Hehlgans, Thomas
author_sort Röhrl, Johann
collection PubMed
description For many years, β-defensins were best known for their antimicrobial activity. However, β-defensins also exert immunomodulatory functions, such as the chemotactic recruitment of immune cells via chemokine receptors. We demonstrated that mouse β-defensin 14 recruits CCR6(+) B cells into fibrosarcomas, resulting in enhanced angiogenesis and tumor development.
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spelling pubmed-34946292012-11-20 Friend or foe: A novel role of β-defensins in tumor development Röhrl, Johann Geissler, Edward K. Hehlgans, Thomas Oncoimmunology Author's View For many years, β-defensins were best known for their antimicrobial activity. However, β-defensins also exert immunomodulatory functions, such as the chemotactic recruitment of immune cells via chemokine receptors. We demonstrated that mouse β-defensin 14 recruits CCR6(+) B cells into fibrosarcomas, resulting in enhanced angiogenesis and tumor development. Landes Bioscience 2012-10-01 /pmc/articles/PMC3494629/ /pubmed/23170263 http://dx.doi.org/10.4161/onci.20825 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Röhrl, Johann
Geissler, Edward K.
Hehlgans, Thomas
Friend or foe: A novel role of β-defensins in tumor development
title Friend or foe: A novel role of β-defensins in tumor development
title_full Friend or foe: A novel role of β-defensins in tumor development
title_fullStr Friend or foe: A novel role of β-defensins in tumor development
title_full_unstemmed Friend or foe: A novel role of β-defensins in tumor development
title_short Friend or foe: A novel role of β-defensins in tumor development
title_sort friend or foe: a novel role of β-defensins in tumor development
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494629/
https://www.ncbi.nlm.nih.gov/pubmed/23170263
http://dx.doi.org/10.4161/onci.20825
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AT hehlgansthomas friendorfoeanovelroleofbdefensinsintumordevelopment

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