Flipping the script on macrophages in leiomyosarcoma

Macrophages promote the growth of leiomyosarcoma (LMS), a malignant soft-tissue tumor. CD47 on tumor cells binds to the macrophagic receptor signal regulatory protein α (SIRPα) and prevents phagocytosis. We showed that anti-CD47 monoclonal antibodies (mAbs) allow macrophages to engulf LMS cells and...

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Detalles Bibliográficos
Autores principales: Edris, Badreddin, Weiskopf, Kipp, Weissman, Irving L., van de Rijn, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494646/
https://www.ncbi.nlm.nih.gov/pubmed/23170280
http://dx.doi.org/10.4161/onci.20799
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author Edris, Badreddin
Weiskopf, Kipp
Weissman, Irving L.
van de Rijn, Matt
author_facet Edris, Badreddin
Weiskopf, Kipp
Weissman, Irving L.
van de Rijn, Matt
author_sort Edris, Badreddin
collection PubMed
description Macrophages promote the growth of leiomyosarcoma (LMS), a malignant soft-tissue tumor. CD47 on tumor cells binds to the macrophagic receptor signal regulatory protein α (SIRPα) and prevents phagocytosis. We showed that anti-CD47 monoclonal antibodies (mAbs) allow macrophages to engulf LMS cells and prevent tumor growth and metastases. Therefore, anti-CD47 mAbs represent a promising targeted immunotherapy for LMS.
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spelling pubmed-34946462012-11-20 Flipping the script on macrophages in leiomyosarcoma Edris, Badreddin Weiskopf, Kipp Weissman, Irving L. van de Rijn, Matt Oncoimmunology Author's View Macrophages promote the growth of leiomyosarcoma (LMS), a malignant soft-tissue tumor. CD47 on tumor cells binds to the macrophagic receptor signal regulatory protein α (SIRPα) and prevents phagocytosis. We showed that anti-CD47 monoclonal antibodies (mAbs) allow macrophages to engulf LMS cells and prevent tumor growth and metastases. Therefore, anti-CD47 mAbs represent a promising targeted immunotherapy for LMS. Landes Bioscience 2012-10-01 /pmc/articles/PMC3494646/ /pubmed/23170280 http://dx.doi.org/10.4161/onci.20799 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Edris, Badreddin
Weiskopf, Kipp
Weissman, Irving L.
van de Rijn, Matt
Flipping the script on macrophages in leiomyosarcoma
title Flipping the script on macrophages in leiomyosarcoma
title_full Flipping the script on macrophages in leiomyosarcoma
title_fullStr Flipping the script on macrophages in leiomyosarcoma
title_full_unstemmed Flipping the script on macrophages in leiomyosarcoma
title_short Flipping the script on macrophages in leiomyosarcoma
title_sort flipping the script on macrophages in leiomyosarcoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494646/
https://www.ncbi.nlm.nih.gov/pubmed/23170280
http://dx.doi.org/10.4161/onci.20799
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AT weissmanirvingl flippingthescriptonmacrophagesinleiomyosarcoma
AT vanderijnmatt flippingthescriptonmacrophagesinleiomyosarcoma

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