Stromal CEACAM1 expression regulates colorectal cancer metastasis

Colorectal cancer metastasis to Ceacam1-/- livers is significantly impaired, compared with wild type livers, due to decreased endothelial cell survival, reduced tumor cell proliferation, diminished immune infiltration and altered chemokine expression. Ceacam1-/- myeloid-derived suppressor cells dimi...

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Detalles Bibliográficos
Autores principales: Arabzadeh, Azadeh, Beauchemin, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494647/
https://www.ncbi.nlm.nih.gov/pubmed/23170281
http://dx.doi.org/10.4161/onci.20735
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author Arabzadeh, Azadeh
Beauchemin, Nicole
author_facet Arabzadeh, Azadeh
Beauchemin, Nicole
author_sort Arabzadeh, Azadeh
collection PubMed
description Colorectal cancer metastasis to Ceacam1-/- livers is significantly impaired, compared with wild type livers, due to decreased endothelial cell survival, reduced tumor cell proliferation, diminished immune infiltration and altered chemokine expression. Ceacam1-/- myeloid-derived suppressor cells diminish metastatic burden, as confirmed by bone marrow transplantation and adoptive transfer experiments.
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spelling pubmed-34946472012-11-20 Stromal CEACAM1 expression regulates colorectal cancer metastasis Arabzadeh, Azadeh Beauchemin, Nicole Oncoimmunology Author's View Colorectal cancer metastasis to Ceacam1-/- livers is significantly impaired, compared with wild type livers, due to decreased endothelial cell survival, reduced tumor cell proliferation, diminished immune infiltration and altered chemokine expression. Ceacam1-/- myeloid-derived suppressor cells diminish metastatic burden, as confirmed by bone marrow transplantation and adoptive transfer experiments. Landes Bioscience 2012-10-01 /pmc/articles/PMC3494647/ /pubmed/23170281 http://dx.doi.org/10.4161/onci.20735 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Arabzadeh, Azadeh
Beauchemin, Nicole
Stromal CEACAM1 expression regulates colorectal cancer metastasis
title Stromal CEACAM1 expression regulates colorectal cancer metastasis
title_full Stromal CEACAM1 expression regulates colorectal cancer metastasis
title_fullStr Stromal CEACAM1 expression regulates colorectal cancer metastasis
title_full_unstemmed Stromal CEACAM1 expression regulates colorectal cancer metastasis
title_short Stromal CEACAM1 expression regulates colorectal cancer metastasis
title_sort stromal ceacam1 expression regulates colorectal cancer metastasis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494647/
https://www.ncbi.nlm.nih.gov/pubmed/23170281
http://dx.doi.org/10.4161/onci.20735
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