Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells

For a long time, cancer immunotherapy has focused on the induction of tumor-specific T cell-mediated immune responses. Now, a mounting body of evidence indicates that efficient anticancer immune responses also rely on innate immunity. Tietze et al. have recently elucidated an antigen-nonspecific rol...

Descripción completa

Detalles Bibliográficos
Autores principales: Sckisel, Gail D., Murphy, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494648/
https://www.ncbi.nlm.nih.gov/pubmed/23170282
http://dx.doi.org/10.4161/onci.20779
_version_ 1782249422786134016
author Sckisel, Gail D.
Murphy, William J.
author_facet Sckisel, Gail D.
Murphy, William J.
author_sort Sckisel, Gail D.
collection PubMed
description For a long time, cancer immunotherapy has focused on the induction of tumor-specific T cell-mediated immune responses. Now, a mounting body of evidence indicates that efficient anticancer immune responses also rely on innate immunity. Tietze et al. have recently elucidated an antigen-nonspecific role for memory CD8(+) T cells in cytokine-based cancer immunotherapy.
format Online
Article
Text
id pubmed-3494648
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-34946482012-11-20 Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells Sckisel, Gail D. Murphy, William J. Oncoimmunology Author's View For a long time, cancer immunotherapy has focused on the induction of tumor-specific T cell-mediated immune responses. Now, a mounting body of evidence indicates that efficient anticancer immune responses also rely on innate immunity. Tietze et al. have recently elucidated an antigen-nonspecific role for memory CD8(+) T cells in cytokine-based cancer immunotherapy. Landes Bioscience 2012-10-01 /pmc/articles/PMC3494648/ /pubmed/23170282 http://dx.doi.org/10.4161/onci.20779 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sckisel, Gail D.
Murphy, William J.
Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells
title Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells
title_full Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells
title_fullStr Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells
title_full_unstemmed Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells
title_short Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells
title_sort specificity may be overrated in cancer immunotherapy: getting to know the nonspecific side of memory t cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494648/
https://www.ncbi.nlm.nih.gov/pubmed/23170282
http://dx.doi.org/10.4161/onci.20779
work_keys_str_mv AT sckiselgaild specificitymaybeoverratedincancerimmunotherapygettingtoknowthenonspecificsideofmemorytcells
AT murphywilliamj specificitymaybeoverratedincancerimmunotherapygettingtoknowthenonspecificsideofmemorytcells

Ejemplares similares