Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice

Low efficacy of peptide vaccines limits their potential application. We developed a powerful strategy to produce epitope-specific antibodies using peptides. Immunization with novel formula into mice showed target-specific prophylactic and therapeutic effects against tumors. Our strategy will be usef...

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Detalles Bibliográficos
Autores principales: Lee, YoungHee, Kwon, Hyung-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494651/
https://www.ncbi.nlm.nih.gov/pubmed/23170285
http://dx.doi.org/10.4161/onci.20404
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author Lee, YoungHee
Kwon, Hyung-Joo
author_facet Lee, YoungHee
Kwon, Hyung-Joo
author_sort Lee, YoungHee
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description Low efficacy of peptide vaccines limits their potential application. We developed a powerful strategy to produce epitope-specific antibodies using peptides. Immunization with novel formula into mice showed target-specific prophylactic and therapeutic effects against tumors. Our strategy will be useful for rapid eiptope screening, therapeutic antibody production and cancer vaccine development.
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spelling pubmed-34946512012-11-20 Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice Lee, YoungHee Kwon, Hyung-Joo Oncoimmunology Author's View Low efficacy of peptide vaccines limits their potential application. We developed a powerful strategy to produce epitope-specific antibodies using peptides. Immunization with novel formula into mice showed target-specific prophylactic and therapeutic effects against tumors. Our strategy will be useful for rapid eiptope screening, therapeutic antibody production and cancer vaccine development. Landes Bioscience 2012-10-01 /pmc/articles/PMC3494651/ /pubmed/23170285 http://dx.doi.org/10.4161/onci.20404 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Lee, YoungHee
Kwon, Hyung-Joo
Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice
title Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice
title_full Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice
title_fullStr Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice
title_full_unstemmed Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice
title_short Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice
title_sort production of epitope-specific antibodies using peptide-cpg-odn-liposome complex without carriers and their application as a cancer vaccine in mice
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494651/
https://www.ncbi.nlm.nih.gov/pubmed/23170285
http://dx.doi.org/10.4161/onci.20404
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