Galectin-3 Impairment of MYCN-Dependent Apoptosis-Sensitive Phenotype Is Antagonized by Nutlin-3 in Neuroblastoma Cells

MYCN amplification occurs in about 20–25% of human neuroblastomas and characterizes the majority of the high-risk cases, which display less than 50% prolonged survival rate despite intense multimodal treatment. Somehow paradoxically, MYCN also sensitizes neuroblastoma cells to apoptosis, understandi...

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Detalles Bibliográficos
Autores principales: Veschi, Veronica, Petroni, Marialaura, Cardinali, Beatrice, Dominici, Carlo, Screpanti, Isabella, Frati, Luigi, Bartolazzi, Armando, Gulino, Alberto, Giannini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494673/
https://www.ncbi.nlm.nih.gov/pubmed/23152863
http://dx.doi.org/10.1371/journal.pone.0049139

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