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A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus

We describe the results of the first genome-wide association study of PTSD performed using trauma-exposed white non-Hispanic participants from a cohort of veterans and their intimate partners (295 cases and 196 controls). Several SNPs yielded evidence of association. One SNP (rs8042149), located in...

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Autores principales: Logue, Mark W., Baldwin, Clinton, Guffanti, Guia, Melista, Efi, Wolf, Erika J., Reardon, Annemarie F., Uddin, Monica, Wildman, Derek, Galea, Sandro, Koenen, Karestan C., Miller, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494788/
https://www.ncbi.nlm.nih.gov/pubmed/22869035
http://dx.doi.org/10.1038/mp.2012.113
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author Logue, Mark W.
Baldwin, Clinton
Guffanti, Guia
Melista, Efi
Wolf, Erika J.
Reardon, Annemarie F.
Uddin, Monica
Wildman, Derek
Galea, Sandro
Koenen, Karestan C.
Miller, Mark W.
author_facet Logue, Mark W.
Baldwin, Clinton
Guffanti, Guia
Melista, Efi
Wolf, Erika J.
Reardon, Annemarie F.
Uddin, Monica
Wildman, Derek
Galea, Sandro
Koenen, Karestan C.
Miller, Mark W.
author_sort Logue, Mark W.
collection PubMed
description We describe the results of the first genome-wide association study of PTSD performed using trauma-exposed white non-Hispanic participants from a cohort of veterans and their intimate partners (295 cases and 196 controls). Several SNPs yielded evidence of association. One SNP (rs8042149), located in the retinoid-related orphan receptor alpha gene (RORA), reached genome-wide significance. Nominally significant associations were observed for other RORA SNPs in two African American replication samples—one from the veteran cohort (43 cases and 41 controls) and another independent cohort (100 cases and 421 controls). However, only the associated SNP from the veteran African American replication sample survived gene-level multiple testing correction. RORA has been implicated in prior GWAS studies of psychiatric disorders and is known to play an important role in neuroprotection and other behaviorally-relevant processes. This study represents an important step towards identifying the genetic underpinnings of PTSD.
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spelling pubmed-34947882014-02-01 A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus Logue, Mark W. Baldwin, Clinton Guffanti, Guia Melista, Efi Wolf, Erika J. Reardon, Annemarie F. Uddin, Monica Wildman, Derek Galea, Sandro Koenen, Karestan C. Miller, Mark W. Mol Psychiatry Article We describe the results of the first genome-wide association study of PTSD performed using trauma-exposed white non-Hispanic participants from a cohort of veterans and their intimate partners (295 cases and 196 controls). Several SNPs yielded evidence of association. One SNP (rs8042149), located in the retinoid-related orphan receptor alpha gene (RORA), reached genome-wide significance. Nominally significant associations were observed for other RORA SNPs in two African American replication samples—one from the veteran cohort (43 cases and 41 controls) and another independent cohort (100 cases and 421 controls). However, only the associated SNP from the veteran African American replication sample survived gene-level multiple testing correction. RORA has been implicated in prior GWAS studies of psychiatric disorders and is known to play an important role in neuroprotection and other behaviorally-relevant processes. This study represents an important step towards identifying the genetic underpinnings of PTSD. 2012-08-07 2013-08 /pmc/articles/PMC3494788/ /pubmed/22869035 http://dx.doi.org/10.1038/mp.2012.113 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Logue, Mark W.
Baldwin, Clinton
Guffanti, Guia
Melista, Efi
Wolf, Erika J.
Reardon, Annemarie F.
Uddin, Monica
Wildman, Derek
Galea, Sandro
Koenen, Karestan C.
Miller, Mark W.
A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
title A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
title_full A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
title_fullStr A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
title_full_unstemmed A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
title_short A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
title_sort genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (rora) gene as a significant risk locus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494788/
https://www.ncbi.nlm.nih.gov/pubmed/22869035
http://dx.doi.org/10.1038/mp.2012.113
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