Cargando…

A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus

We describe the results of the first genome-wide association study of PTSD performed using trauma-exposed white non-Hispanic participants from a cohort of veterans and their intimate partners (295 cases and 196 controls). Several SNPs yielded evidence of association. One SNP (rs8042149), located in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Logue, Mark W., Baldwin, Clinton, Guffanti, Guia, Melista, Efi, Wolf, Erika J., Reardon, Annemarie F., Uddin, Monica, Wildman, Derek, Galea, Sandro, Koenen, Karestan C., Miller, Mark W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494788/ https://www.ncbi.nlm.nih.gov/pubmed/22869035 http://dx.doi.org/10.1038/mp.2012.113

Ejemplares similares

RORA and posttraumatic stress trajectories: main effects and interactions with childhood physical abuse history
por: Lowe, Sarah R, et al.
Publicado: (2015)

Considering trauma exposure in the context of genetics studies of posttraumatic stress disorder: a systematic review
por: DiGangi, Julia, et al.
Publicado: (2013)

Interaction between Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) and Neuropeptide S Receptor 1 (NPSR1) in Asthma
por: Acevedo, Nathalie, et al.
Publicado: (2013)

Ancient evolutionary origins of epigenetic regulation associated with posttraumatic stress disorder
por: Sipahi, Levent, et al.
Publicado: (2014)

Molecular Variation at the SLC6A3 Locus Predicts Lifetime Risk of PTSD in the Detroit Neighborhood Health Study
por: Chang, Shun-Chiao, et al.
Publicado: (2012)

The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed
por: Yiğit, Serbulent, et al.
Publicado: (2023)

Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study
por: Polimanti, Renato, et al.
Publicado: (2019)

Gene Expression and Methylation Signatures of MAN2C1 are Associated with PTSD
por: Uddin, Monica, et al.
Publicado: (2011)

Epigenetic predictors of all-cause mortality are associated with objective measures of neighborhood disadvantage in an urban population
por: Ward-Caviness, Cavin K., et al.
Publicado: (2020)

RORA and Autism in The Isfahan Population: Is There An Epigenetic Relationship
por: Salehi, Mansoor, et al.
Publicado: (2017)

Rora Regulates Neutrophil Migration and Activation in Zebrafish
por: Hsu, Alan Y., et al.
Publicado: (2022)

Association of Posttraumatic Stress and Depressive Symptoms With Mortality in Women
por: Roberts, Andrea L., et al.
Publicado: (2020)

Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma
por: Meissburger, Bettina, et al.
Publicado: (2011)

Novel Therapeutic Potential of Retinoid-Related Orphan Receptor α in Cardiovascular Diseases
por: Chen, Yun, et al.
Publicado: (2023)

Role of simvastatin and RORa activity in the macrophage apoptotic pathway
por: Çoban, Neslihan, et al.
Publicado: (2017)

The role of retinoid-related orphan receptor-α in cigarette smoke-induced autophagic response
por: Kim, Hak-Su, et al.
Publicado: (2022)

Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II
por: Koenen, Karestan C, et al.
Publicado: (2009)

Neighborhood environment, social cohesion, and epigenetic aging
por: Martin, Chantel L., et al.
Publicado: (2021)

The Retinoid-Related Orphan Receptor RORα Promotes Keratinocyte Differentiation via FOXN1
por: Dai, Jun, et al.
Publicado: (2013)

An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons
por: Liu, Hong, et al.
Publicado: (2013)

Transcription Factor Retinoid-Related Orphan Receptor γt: A Promising Target for the Treatment of Psoriasis
por: Tang, Lipeng, et al.
Publicado: (2018)

Retinoid receptor-related orphan receptor alpha: a key gene setting brain circuits
por: Vitalis, Tania, et al.
Publicado: (2018)

Mapping Rora expression in resting and activated CD4+ T cells
por: Haim-Vilmovsky, Liora, et al.
Publicado: (2021)

Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women
por: Thurston, Rebecca C., et al.
Publicado: (2023)

Trauma, Posttraumatic Stress Disorder, and Treatment Among Middle-Aged And Older Women
por: Sampson, Laura, et al.
Publicado: (2021)

Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome
por: Hicks, Emily M., et al.
Publicado: (2023)

Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
por: Jetten, Anton M.
Publicado: (2009)

Nuclear receptor retinoid-related orphan receptor alpha promotes apoptosis but is reduced in human gastric cancer
por: Wang, Zhengguang, et al.
Publicado: (2016)

The nuclear retinoid‐related orphan receptor ROR α controls circadian thermogenic programming in white fat depots
por: Monnier, Chloé, et al.
Publicado: (2018)

Lack of retinoid acid receptor-related orphan receptor alpha accelerates and melatonin supplementation prevents testicular aging
por: Sayed, Ramy K. A., et al.
Publicado: (2020)

National and regional prevalence of posttraumatic stress disorder in sub-Saharan Africa: A systematic review and meta-analysis
por: Ng, Lauren C., et al.
Publicado: (2020)

Trauma and posttraumatic stress disorder in South Africa: analysis from the South African Stress and Health Study
por: Atwoli, Lukoye, et al.
Publicado: (2013)

Correction: National and regional prevalence of posttraumatic stress disorder in sub-Saharan Africa: A systematic review and meta-analysis
por: Ng, Lauren C., et al.
Publicado: (2020)

The Role of Genes in Defining a Molecular Biology of PTSD
por: Yehuda, Rachel, et al.
Publicado: (2011)

Investigation of Associations between NR1D1, RORA and RORB Genes and Bipolar Disorder
por: Lai, Yin-Chieh, et al.
Publicado: (2015)

Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes
por: Takeda, Yukimasa, et al.
Publicado: (2014)

RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response
por: Hennings, J M, et al.
Publicado: (2015)

11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ
por: Beck, Katharina R., et al.
Publicado: (2019)

Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample
por: Uddin, M., et al.
Publicado: (2011)

Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility
por: Benna, Clara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_63kg1pvmqjcuo5dbh3lrf8mh7e