PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells()

Two cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability. Approximately 5–10% of breast and ovarian cancers result from inherited alterations or mutations in...

Descripción completa

Detalles Bibliográficos
Autores principales: Węsierska-Gądek, Józefa, Zulehner, Nora, Ferk, Franziska, Składanowski, Andrzej, Komina, Oxana, Maurer, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494830/
https://www.ncbi.nlm.nih.gov/pubmed/22906755
http://dx.doi.org/10.1016/j.bcp.2012.07.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494830/
https://www.ncbi.nlm.nih.gov/pubmed/22906755
http://dx.doi.org/10.1016/j.bcp.2012.07.024

Ejemplares similares