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Cell biology: A key driver of therapeutic innovation

All processes associated with cellular function are likely to contribute to disease. Particularly in the cancer field, most major therapeutic innovations have originated from the elucidation of basic molecular mechanisms by academic researchers. Recent breakthroughs in molecularly targeted drug disc...

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Detalles Bibliográficos
Autores principales: Hantschel, Oliver, Superti-Furga, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494851/
https://www.ncbi.nlm.nih.gov/pubmed/23148230
http://dx.doi.org/10.1083/jcb.201208111
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author Hantschel, Oliver
Superti-Furga, Giulio
author_facet Hantschel, Oliver
Superti-Furga, Giulio
author_sort Hantschel, Oliver
collection PubMed
description All processes associated with cellular function are likely to contribute to disease. Particularly in the cancer field, most major therapeutic innovations have originated from the elucidation of basic molecular mechanisms by academic researchers. Recent breakthroughs in molecularly targeted drug discovery have made it clear that it is the depth with which a biological process is understood that empowers its translation. We propose that early, more strategic, support of cutting-edge academic research by industry may be more effective for translational purposes than the current model of a late selection of community-evolved projects.
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spelling pubmed-34948512013-05-12 Cell biology: A key driver of therapeutic innovation Hantschel, Oliver Superti-Furga, Giulio J Cell Biol News All processes associated with cellular function are likely to contribute to disease. Particularly in the cancer field, most major therapeutic innovations have originated from the elucidation of basic molecular mechanisms by academic researchers. Recent breakthroughs in molecularly targeted drug discovery have made it clear that it is the depth with which a biological process is understood that empowers its translation. We propose that early, more strategic, support of cutting-edge academic research by industry may be more effective for translational purposes than the current model of a late selection of community-evolved projects. The Rockefeller University Press 2012-11-12 /pmc/articles/PMC3494851/ /pubmed/23148230 http://dx.doi.org/10.1083/jcb.201208111 Text en © 2012 Hantschel and Superti-Furga This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle News
Hantschel, Oliver
Superti-Furga, Giulio
Cell biology: A key driver of therapeutic innovation
title Cell biology: A key driver of therapeutic innovation
title_full Cell biology: A key driver of therapeutic innovation
title_fullStr Cell biology: A key driver of therapeutic innovation
title_full_unstemmed Cell biology: A key driver of therapeutic innovation
title_short Cell biology: A key driver of therapeutic innovation
title_sort cell biology: a key driver of therapeutic innovation
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494851/
https://www.ncbi.nlm.nih.gov/pubmed/23148230
http://dx.doi.org/10.1083/jcb.201208111
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