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Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity

The Forkhead transcription factor, FoxO3a induces genomic death responses in neurones following translocation from the cytosol to the nucleus. Nuclear translocation of FoxO3a is triggered by trophic factor withdrawal, oxidative stress and the stimulation of extrasynaptic NMDA receptors. Receptor act...

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Detalles Bibliográficos
Autores principales:	Bahia, Parmvir K, Pugh, Victoria, Hoyland, Kimberley, Hensley, Victoria, Rattray, Marcus, Williams, Robert J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494983/ https://www.ncbi.nlm.nih.gov/pubmed/22804756 http://dx.doi.org/10.1111/j.1471-4159.2012.07877.x

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