SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity

BACKGROUND: Small proline rich protein (SPRR) 2A is one of 14 SPRR genes that encodes for a skin cross-linking protein, which confers structural integrity to the cornified keratinocyte cell envelope. New evidence, however, shows that SPRR2A is also a critical stress and wound repair modulator: it en...

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Detalles Bibliográficos
Autores principales: Mizuguchi, Yoshiaki, Specht, Susan, Lunz, John G, Isse, Kumiko, Corbitt, Natasha, Takizawa, Toshihiro, Demetris, Anthony J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495018/
https://www.ncbi.nlm.nih.gov/pubmed/22731250
http://dx.doi.org/10.1186/1471-2199-13-20

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