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The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening
Wear particle-induced periprosthetic osteolysis remains the principal cause of aseptic loosening of orthopaedic implants. Monocytes/macrophages phagocytose wear particles and release cytokines that induce inflammatory response. This response promotes osteoclast differentiation and osteolysis. The pr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495264/ https://www.ncbi.nlm.nih.gov/pubmed/23193363 http://dx.doi.org/10.1155/2012/596870 |
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author | Gu, Qiaoli Shi, Qin Yang, Huilin |
author_facet | Gu, Qiaoli Shi, Qin Yang, Huilin |
author_sort | Gu, Qiaoli |
collection | PubMed |
description | Wear particle-induced periprosthetic osteolysis remains the principal cause of aseptic loosening of orthopaedic implants. Monocytes/macrophages phagocytose wear particles and release cytokines that induce inflammatory response. This response promotes osteoclast differentiation and osteolysis. The precise mechanisms by which wear particles are recognized and induce the accumulation of inflammatory cells in the periprosthetic tissue have not been fully elucidated. Recent studies have shown that toll-like receptors (TLRs) contribute to the cellular interaction with wear particles. Wear particles are recognized by monocytes/macrophages through TLRs coupled with the adaptor protein MyD88. After the initial interaction, wear particles induce both local and systemic migration of monocytes/macrophages to the periprosthetic region. The cellular migration is mediated through chemokines including interleukin-8, macrophage chemotactic protein-1, and macrophage inhibitory protein-1 in the periprosthetic tissues. Interfering with chemokine-receptor axis can inhibit cellular migration and inflammatory response. This paper highlights recent advances in TLR, and chemokine participated in the pathogenesis of aseptic loosening. A comprehensive understanding of the recognition and migration mechanism is critical to the development of measures that prevent wear particle-induced aseptic loosening of orthopaedic implants. |
format | Online Article Text |
id | pubmed-3495264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34952642012-11-28 The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening Gu, Qiaoli Shi, Qin Yang, Huilin J Biomed Biotechnol Review Article Wear particle-induced periprosthetic osteolysis remains the principal cause of aseptic loosening of orthopaedic implants. Monocytes/macrophages phagocytose wear particles and release cytokines that induce inflammatory response. This response promotes osteoclast differentiation and osteolysis. The precise mechanisms by which wear particles are recognized and induce the accumulation of inflammatory cells in the periprosthetic tissue have not been fully elucidated. Recent studies have shown that toll-like receptors (TLRs) contribute to the cellular interaction with wear particles. Wear particles are recognized by monocytes/macrophages through TLRs coupled with the adaptor protein MyD88. After the initial interaction, wear particles induce both local and systemic migration of monocytes/macrophages to the periprosthetic region. The cellular migration is mediated through chemokines including interleukin-8, macrophage chemotactic protein-1, and macrophage inhibitory protein-1 in the periprosthetic tissues. Interfering with chemokine-receptor axis can inhibit cellular migration and inflammatory response. This paper highlights recent advances in TLR, and chemokine participated in the pathogenesis of aseptic loosening. A comprehensive understanding of the recognition and migration mechanism is critical to the development of measures that prevent wear particle-induced aseptic loosening of orthopaedic implants. Hindawi Publishing Corporation 2012 2012-10-21 /pmc/articles/PMC3495264/ /pubmed/23193363 http://dx.doi.org/10.1155/2012/596870 Text en Copyright © 2012 Qiaoli Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gu, Qiaoli Shi, Qin Yang, Huilin The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening |
title | The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening |
title_full | The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening |
title_fullStr | The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening |
title_full_unstemmed | The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening |
title_short | The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening |
title_sort | role of tlr and chemokine in wear particle-induced aseptic loosening |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495264/ https://www.ncbi.nlm.nih.gov/pubmed/23193363 http://dx.doi.org/10.1155/2012/596870 |
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