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A universally conserved residue in the SUR1 subunit of the K(ATP) channel is essential for translating nucleotide binding at SUR1 into channel opening

The sulphonylurea receptor (SUR1) subunit of the ATP-sensitive potassium (K(ATP)) channel is a member of the ATP-binding cassette (ABC) protein family. Binding of MgADP to nucleotide-binding domain 2 (NBD2) is critical for channel activation. We identified a residue in NBD2 (G1401) that is fully con...

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Detalles Bibliográficos
Autores principales:	de Wet, Heidi, Shimomura, Kenju, Aittoniemi, Jussi, Ahmad, Nawaz, Lafond, Mathilde, Sansom, Mark SP, Ashcroft, Frances M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Science Inc 2012
Materias:	Molecular and Cellular
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495298/ https://www.ncbi.nlm.nih.gov/pubmed/22802590 http://dx.doi.org/10.1113/jphysiol.2012.236075

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