Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice

BACKGROUND: Oxaliplatin, a platinum-based chemotherapeutic agent, causes an unusual acute peripheral neuropathy. Oxaliplatin-induced acute peripheral neuropathy appears in almost all patients rapidly after infusion, and is triggered or exacerbated by cold, while its mechanisms are poorly understood....

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Detalles Bibliográficos
Autores principales: Zhao, Meng, Isami, Kouichi, Nakamura, Saki, Shirakawa, Hisashi, Nakagawa, Takayuki, Kaneko, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495669/
https://www.ncbi.nlm.nih.gov/pubmed/22839205
http://dx.doi.org/10.1186/1744-8069-8-55

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