Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons

BACKGROUND: Gain-of-function mutations of the nociceptive voltage-gated sodium channel Nav1.7 lead to inherited pain syndromes, such as paroxysmal extreme pain disorder (PEPD). One characteristic of these mutations is slowed fast-inactivation kinetics, which may give rise to resurgent sodium current...

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Detalles Bibliográficos
Autores principales: Klinger, Alexandra B, Eberhardt, Mirjam, Link, Andrea S, Namer, Barbara, Kutsche, Lisa K, Schuy, E Theresa, Sittl, Ruth, Hoffmann, Tali, Alzheimer, Christian, Huth, Tobias, Carr, Richard W, Lampert, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495684/
https://www.ncbi.nlm.nih.gov/pubmed/22978421
http://dx.doi.org/10.1186/1744-8069-8-69

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