Allele-Specific Gene Silencing in Two Mouse Models of Autosomal Dominant Skeletal Myopathy

We explored the potential of mutant allele-specific gene silencing (ASGS) in providing therapeutic benefit in two established mouse models of the autosomal dominantly-inherited muscle disorders, Malignant Hyperthermia (MH) and Central Core Disease (CCD). Candidate ASGS siRNAs were designed and valid...

Descripción completa

Detalles Bibliográficos
Autores principales: Loy, Ryan E., Lueck, John D., Mostajo-Radji, Mohammed A., Carrell, Ellie M., Dirksen, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495761/
https://www.ncbi.nlm.nih.gov/pubmed/23152933
http://dx.doi.org/10.1371/journal.pone.0049757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495761/
https://www.ncbi.nlm.nih.gov/pubmed/23152933
http://dx.doi.org/10.1371/journal.pone.0049757

Ejemplares similares