Paneth cells and necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and fun...

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Detalles Bibliográficos
Autor principal: Underwood, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Article Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495794/
https://www.ncbi.nlm.nih.gov/pubmed/22895084
http://dx.doi.org/10.4161/gmic.21738
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author Underwood, Mark A.
author_facet Underwood, Mark A.
author_sort Underwood, Mark A.
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description Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the puzzling pathophysiology of NEC. Current animal models of NEC are limited in their capacity to answer these questions.
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spelling pubmed-34957942012-11-20 Paneth cells and necrotizing enterocolitis Underwood, Mark A. Gut Microbes Article Addendum Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the puzzling pathophysiology of NEC. Current animal models of NEC are limited in their capacity to answer these questions. Landes Bioscience 2012-11-01 /pmc/articles/PMC3495794/ /pubmed/22895084 http://dx.doi.org/10.4161/gmic.21738 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Article Addendum
Underwood, Mark A.
Paneth cells and necrotizing enterocolitis
title Paneth cells and necrotizing enterocolitis
title_full Paneth cells and necrotizing enterocolitis
title_fullStr Paneth cells and necrotizing enterocolitis
title_full_unstemmed Paneth cells and necrotizing enterocolitis
title_short Paneth cells and necrotizing enterocolitis
title_sort paneth cells and necrotizing enterocolitis
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495794/
https://www.ncbi.nlm.nih.gov/pubmed/22895084
http://dx.doi.org/10.4161/gmic.21738
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