Lack of Bcr and Abr Promotes Hypoxia-Induced Pulmonary Hypertension in Mice

BACKGROUND: Bcr and Abr are GTPase activating proteins that specifically downregulate activity of the small GTPase Rac in restricted cell types in vivo. Rac1 is expressed in smooth muscle cells, a critical cell type involved in the pathogenesis of pulmonary hypertension. The molecular mechanisms tha...

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Detalles Bibliográficos
Autores principales: Yu, Min, Gong, Dapeng, Lim, Min, Arutyunyan, Anna, Groffen, John, Heisterkamp, Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495860/
https://www.ncbi.nlm.nih.gov/pubmed/23152932
http://dx.doi.org/10.1371/journal.pone.0049756

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