Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

BACKGROUND: Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to chemotherapy drugs in cancer patients. METHODS: To investigate this hypothesis, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Heibein, Allan D, Guo, Baoqing, Sprowl, Jason A, MacLean, David A, Parissenti, Amadeo M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495881/
https://www.ncbi.nlm.nih.gov/pubmed/22938713
http://dx.doi.org/10.1186/1471-2407-12-381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495881/
https://www.ncbi.nlm.nih.gov/pubmed/22938713
http://dx.doi.org/10.1186/1471-2407-12-381

Ejemplares similares