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Inhibition of 5′-UTR RNA Conformational Switching in HIV-1 Using Antisense PNAs
BACKGROUND: The genome of retroviruses, including HIV-1, is packaged as two homologous (+) strand RNA molecules, noncovalently associated close to their 5′-end in a region called dimer linkage structure (DLS). Retroviral HIV-1 genomic RNAs dimerize through complex interactions between dimerization i...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495914/ https://www.ncbi.nlm.nih.gov/pubmed/23152893 http://dx.doi.org/10.1371/journal.pone.0049310 |