Establishment and Characterization of a Highly Tumourigenic and Cancer Stem Cell Enriched Pancreatic Cancer Cell Line as a Well Defined Model System

Standard cancer cell lines do not model the intratumoural heterogeneity situation sufficiently. Clonal selection leads to a homogeneous population of cells by genetic drift. Heterogeneity of tumour cells, however, is particularly critical for therapeutically relevant studies, since it is a prerequis...

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Detalles Bibliográficos
Autores principales: Fredebohm, Johannes, Boettcher, Michael, Eisen, Christian, Gaida, Matthias M., Heller, Anette, Keleg, Shereen, Tost, Jörg, Greulich-Bode, Karin M., Hotz-Wagenblatt, Agnes, Lathrop, Mark, Giese, Nathalia A., Hoheisel, Jörg D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495919/
https://www.ncbi.nlm.nih.gov/pubmed/23152778
http://dx.doi.org/10.1371/journal.pone.0048503

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