Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-ste...

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Detalles Bibliográficos
Autores principales: van Lierop, Marie-José C., Alkema, Wynand, Laskewitz, Anke J., Dijkema, Rein, van der Maaden, Hans M., Smit, Martin J., Plate, Ralf, Conti, Paolo G. M., Jans, Christan G. J. M., Timmers, C. Marco, van Boeckel, Constant A. A., Lusher, Scott J., McGuire, Ross, van Schaik, Rene C., de Vlieg, Jacob, Smeets, Ruben L., Hofstra, Claudia L., Boots, Annemieke M. H., van Duin, Marcel, Ingelse, Benno A., Schoonen, Willem G. E. J., Grefhorst, Aldo, van Dijk, Theo H., Kuipers, Folkert, Dokter, Wim H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495945/
https://www.ncbi.nlm.nih.gov/pubmed/23152771
http://dx.doi.org/10.1371/journal.pone.0048385

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