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Cyclic Stretch Induces Cell Reorientation on Substrates by Destabilizing Catch Bonds in Focal Adhesions
A minimal model of cellular mechanosensing system that consists of a single stress fiber adhering on a substrate via two focal adhesions made of catch bonds is adopted to investigate the phenomena of cell reorientation on substrates induced by an applied uniaxial cyclic stretch. The model indicates...
Autores principales: | Chen, Bin, Kemkemer, Ralf, Deibler, Martin, Spatz, Joachim, Gao, Huajian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495948/ https://www.ncbi.nlm.nih.gov/pubmed/23152769 http://dx.doi.org/10.1371/journal.pone.0048346 |
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