Neural Progenitor Cells Regulate Microglia Functions and Activity States

We observed that mouse neural progenitor cells (NPCs) have a secretory protein profile distinct from other brain cells and modulate microglial activation, proliferation, and phagocytosis in culture and in vivo. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at l...

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Detalles Bibliográficos
Autores principales: Mosher, Kira I., Andres, Robert H., Fukuhara, Takeshi, Bieri, Gregor, Hasegawa-Moriyama, Maiko, He, Yingbo, Guzman, Raphael, Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495979/
https://www.ncbi.nlm.nih.gov/pubmed/23086334
http://dx.doi.org/10.1038/nn.3233
Descripción
Sumario:We observed that mouse neural progenitor cells (NPCs) have a secretory protein profile distinct from other brain cells and modulate microglial activation, proliferation, and phagocytosis in culture and in vivo. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Neural stem or precursor cells may thus not only be shaped by microglia but regulate in turn microglia functions and activity.

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