Neural Progenitor Cells Regulate Microglia Functions and Activity States

We observed that mouse neural progenitor cells (NPCs) have a secretory protein profile distinct from other brain cells and modulate microglial activation, proliferation, and phagocytosis in culture and in vivo. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at l...

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Autores principales: Mosher, Kira I., Andres, Robert H., Fukuhara, Takeshi, Bieri, Gregor, Hasegawa-Moriyama, Maiko, He, Yingbo, Guzman, Raphael, Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495979/
https://www.ncbi.nlm.nih.gov/pubmed/23086334
http://dx.doi.org/10.1038/nn.3233
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author Mosher, Kira I.
Andres, Robert H.
Fukuhara, Takeshi
Bieri, Gregor
Hasegawa-Moriyama, Maiko
He, Yingbo
Guzman, Raphael
Wyss-Coray, Tony
author_facet Mosher, Kira I.
Andres, Robert H.
Fukuhara, Takeshi
Bieri, Gregor
Hasegawa-Moriyama, Maiko
He, Yingbo
Guzman, Raphael
Wyss-Coray, Tony
author_sort Mosher, Kira I.
collection PubMed
description We observed that mouse neural progenitor cells (NPCs) have a secretory protein profile distinct from other brain cells and modulate microglial activation, proliferation, and phagocytosis in culture and in vivo. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Neural stem or precursor cells may thus not only be shaped by microglia but regulate in turn microglia functions and activity.
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spelling pubmed-34959792013-05-01 Neural Progenitor Cells Regulate Microglia Functions and Activity States Mosher, Kira I. Andres, Robert H. Fukuhara, Takeshi Bieri, Gregor Hasegawa-Moriyama, Maiko He, Yingbo Guzman, Raphael Wyss-Coray, Tony Nat Neurosci Article We observed that mouse neural progenitor cells (NPCs) have a secretory protein profile distinct from other brain cells and modulate microglial activation, proliferation, and phagocytosis in culture and in vivo. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Neural stem or precursor cells may thus not only be shaped by microglia but regulate in turn microglia functions and activity. 2012-10-21 2012-11 /pmc/articles/PMC3495979/ /pubmed/23086334 http://dx.doi.org/10.1038/nn.3233 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mosher, Kira I.
Andres, Robert H.
Fukuhara, Takeshi
Bieri, Gregor
Hasegawa-Moriyama, Maiko
He, Yingbo
Guzman, Raphael
Wyss-Coray, Tony
Neural Progenitor Cells Regulate Microglia Functions and Activity States
title Neural Progenitor Cells Regulate Microglia Functions and Activity States
title_full Neural Progenitor Cells Regulate Microglia Functions and Activity States
title_fullStr Neural Progenitor Cells Regulate Microglia Functions and Activity States
title_full_unstemmed Neural Progenitor Cells Regulate Microglia Functions and Activity States
title_short Neural Progenitor Cells Regulate Microglia Functions and Activity States
title_sort neural progenitor cells regulate microglia functions and activity states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495979/
https://www.ncbi.nlm.nih.gov/pubmed/23086334
http://dx.doi.org/10.1038/nn.3233
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