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Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
INTRODUCTION: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B),...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496151/ https://www.ncbi.nlm.nih.gov/pubmed/22348646 http://dx.doi.org/10.1186/bcr3121 |
| _version_ | 1782249610992943104 |
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| author | Antoniou, Antonis C Kuchenbaecker, Karoline B Soucy, Penny Beesley, Jonathan Chen, Xiaoqing McGuffog, Lesley Lee, Andrew Barrowdale, Daniel Healey, Sue Sinilnikova, Olga M Caligo, Maria A Loman, Niklas Harbst, Katja Lindblom, Annika Arver, Brita Rosenquist, Richard Karlsson, Per Nathanson, Kate Domchek, Susan Rebbeck, Tim Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Złowowcka-Perłowska, Elżbieta Osorio, Ana Durán, Mercedes Andrés, Raquel Benítez, Javier Hamann, Ute Hogervorst, Frans B van Os , Theo A Verhoef, Senno Meijers-Heijboer, Hanne EJ Wijnen, Juul Gómez Garcia, Encarna B Ligtenberg, Marjolijn J Kriege, Mieke Collée, J Margriet Ausems, Margreet GEM Oosterwijk, Jan C Peock, Susan Frost, Debra Ellis, Steve D Platte, Radka Fineberg, Elena Evans, D Gareth Lalloo, Fiona Jacobs, Chris Eeles, Ros Adlard, Julian Davidson, Rosemarie Cole, Trevor Cook, Jackie Paterson, Joan Douglas, Fiona Brewer, Carole Hodgson, Shirley Morrison, Patrick J Walker, Lisa Rogers, Mark T Donaldson, Alan Dorkins, Huw Godwin, Andrew K Bove, Betsy Stoppa-Lyonnet, Dominique Houdayer, Claude Buecher, Bruno de Pauw, Antoine Mazoyer, Sylvie Calender, Alain Léoné, Mélanie Bressac- de Paillerets, Brigitte Caron, Olivier Sobol, Hagay Frenay, Marc Prieur, Fabienne Ferrer, Sandra Fert Mortemousque, Isabelle Buys, Saundra Daly, Mary Miron, Alexander Terry, Mary Beth Hopper, John L John, Esther M Southey, Melissa Goldgar, David Singer, Christian F Fink-Retter, Anneliese Tea, Muy-Kheng Kaulich, Daphne Geschwantler Hansen, Thomas VO Nielsen, Finn C Barkardottir, Rosa B Gaudet, Mia Kirchhoff, Tomas Joseph, Vijai Dutra-Clarke, Ana Offit, Kenneth Piedmonte, Marion Kirk, Judy Cohn, David Hurteau, Jean Byron, John Fiorica, James Toland, Amanda E Montagna, Marco Oliani, Cristina Imyanitov, Evgeny Isaacs, Claudine Tihomirova, Laima Blanco, Ignacio Lazaro, Conxi Teulé, Alex Valle, J Del Gayther, Simon A Odunsi, Kunle Gross, Jenny Karlan, Beth Y Olah, Edith Teo, Soo-Hwang Ganz, Patricia A Beattie, Mary S Dorfling, Cecelia M van Rensburg, Elizabeth Jansen Diez, Orland Kwong, Ava Schmutzler, Rita K Wappenschmidt, Barbara Engel, Christoph Meindl, Alfons Ditsch, Nina Arnold, Norbert Heidemann, Simone Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorothea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Fiebig, Britta Schäfer, Dieter Caldes, Trinidad de la Hoya, Miguel Nevanlinna, Heli Muranen, Taru A Lespérance, Bernard Spurdle, Amanda B Neuhausen, Susan L Ding, Yuan C Wang, Xianshu Fredericksen, Zachary Pankratz, Vernon S Lindor, Noralane M Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Bonanni, Bernardo Bernard, Loris Dolcetti, Riccardo Papi, Laura Ottini, Laura Radice, Paolo Greene, Mark H Loud, Jennifer T Andrulis, Irene L Ozcelik, Hilmi Mulligan, Anna Marie Glendon, Gord Thomassen, Mads Gerdes, Anne-Marie Jensen, Uffe B Skytte, Anne-Bine Kruse, Torben A Chenevix-Trench, Georgia Couch, Fergus J Simard, Jacques Easton, Douglas F |
| author_facet | Antoniou, Antonis C Kuchenbaecker, Karoline B Soucy, Penny Beesley, Jonathan Chen, Xiaoqing McGuffog, Lesley Lee, Andrew Barrowdale, Daniel Healey, Sue Sinilnikova, Olga M Caligo, Maria A Loman, Niklas Harbst, Katja Lindblom, Annika Arver, Brita Rosenquist, Richard Karlsson, Per Nathanson, Kate Domchek, Susan Rebbeck, Tim Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Złowowcka-Perłowska, Elżbieta Osorio, Ana Durán, Mercedes Andrés, Raquel Benítez, Javier Hamann, Ute Hogervorst, Frans B van Os , Theo A Verhoef, Senno Meijers-Heijboer, Hanne EJ Wijnen, Juul Gómez Garcia, Encarna B Ligtenberg, Marjolijn J Kriege, Mieke Collée, J Margriet Ausems, Margreet GEM Oosterwijk, Jan C Peock, Susan Frost, Debra Ellis, Steve D Platte, Radka Fineberg, Elena Evans, D Gareth Lalloo, Fiona Jacobs, Chris Eeles, Ros Adlard, Julian Davidson, Rosemarie Cole, Trevor Cook, Jackie Paterson, Joan Douglas, Fiona Brewer, Carole Hodgson, Shirley Morrison, Patrick J Walker, Lisa Rogers, Mark T Donaldson, Alan Dorkins, Huw Godwin, Andrew K Bove, Betsy Stoppa-Lyonnet, Dominique Houdayer, Claude Buecher, Bruno de Pauw, Antoine Mazoyer, Sylvie Calender, Alain Léoné, Mélanie Bressac- de Paillerets, Brigitte Caron, Olivier Sobol, Hagay Frenay, Marc Prieur, Fabienne Ferrer, Sandra Fert Mortemousque, Isabelle Buys, Saundra Daly, Mary Miron, Alexander Terry, Mary Beth Hopper, John L John, Esther M Southey, Melissa Goldgar, David Singer, Christian F Fink-Retter, Anneliese Tea, Muy-Kheng Kaulich, Daphne Geschwantler Hansen, Thomas VO Nielsen, Finn C Barkardottir, Rosa B Gaudet, Mia Kirchhoff, Tomas Joseph, Vijai Dutra-Clarke, Ana Offit, Kenneth Piedmonte, Marion Kirk, Judy Cohn, David Hurteau, Jean Byron, John Fiorica, James Toland, Amanda E Montagna, Marco Oliani, Cristina Imyanitov, Evgeny Isaacs, Claudine Tihomirova, Laima Blanco, Ignacio Lazaro, Conxi Teulé, Alex Valle, J Del Gayther, Simon A Odunsi, Kunle Gross, Jenny Karlan, Beth Y Olah, Edith Teo, Soo-Hwang Ganz, Patricia A Beattie, Mary S Dorfling, Cecelia M van Rensburg, Elizabeth Jansen Diez, Orland Kwong, Ava Schmutzler, Rita K Wappenschmidt, Barbara Engel, Christoph Meindl, Alfons Ditsch, Nina Arnold, Norbert Heidemann, Simone Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorothea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Fiebig, Britta Schäfer, Dieter Caldes, Trinidad de la Hoya, Miguel Nevanlinna, Heli Muranen, Taru A Lespérance, Bernard Spurdle, Amanda B Neuhausen, Susan L Ding, Yuan C Wang, Xianshu Fredericksen, Zachary Pankratz, Vernon S Lindor, Noralane M Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Bonanni, Bernardo Bernard, Loris Dolcetti, Riccardo Papi, Laura Ottini, Laura Radice, Paolo Greene, Mark H Loud, Jennifer T Andrulis, Irene L Ozcelik, Hilmi Mulligan, Anna Marie Glendon, Gord Thomassen, Mads Gerdes, Anne-Marie Jensen, Uffe B Skytte, Anne-Bine Kruse, Torben A Chenevix-Trench, Georgia Couch, Fergus J Simard, Jacques Easton, Douglas F |
| author_sort | Antoniou, Antonis C |
| collection | PubMed |
| description | INTRODUCTION: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2). METHODS: To evaluate whether these single nucleotide polymorphisms (SNPs) are associated with breast cancer risk for BRCA1 and BRCA2 carriers, we genotyped these SNPs in 12,599 BRCA1 and 7,132 BRCA2 mutation carriers and analysed the associations with breast cancer risk within a retrospective likelihood framework. RESULTS: Only SNP rs10771399 near PTHLH was associated with breast cancer risk for BRCA1 mutation carriers (per-allele hazard ratio (HR) = 0.87, 95% CI: 0.81 to 0.94, P-trend = 3 × 10(-4)). The association was restricted to mutations proven or predicted to lead to absence of protein expression (HR = 0.82, 95% CI: 0.74 to 0.90, P-trend = 3.1 × 10(-5), P-difference = 0.03). Four SNPs were associated with the risk of breast cancer for BRCA2 mutation carriers: rs10995190, P-trend = 0.015; rs1011970, P-trend = 0.048; rs865686, 2df-P = 0.007; rs1292011 2df-P = 0.03. rs10771399 (PTHLH) was predominantly associated with estrogen receptor (ER)-negative breast cancer for BRCA1 mutation carriers (HR = 0.81, 95% CI: 0.74 to 0.90, P-trend = 4 × 10(-5)) and there was marginal evidence of association with ER-negative breast cancer for BRCA2 mutation carriers (HR = 0.78, 95% CI: 0.62 to 1.00, P-trend = 0.049). CONCLUSIONS: The present findings, in combination with previously identified modifiers of risk, will ultimately lead to more accurate risk prediction and an improved understanding of the disease etiology in BRCA1 and BRCA2 mutation carriers. |
| format | Online Article Text |
| id | pubmed-3496151 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34961512012-11-14 Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers Antoniou, Antonis C Kuchenbaecker, Karoline B Soucy, Penny Beesley, Jonathan Chen, Xiaoqing McGuffog, Lesley Lee, Andrew Barrowdale, Daniel Healey, Sue Sinilnikova, Olga M Caligo, Maria A Loman, Niklas Harbst, Katja Lindblom, Annika Arver, Brita Rosenquist, Richard Karlsson, Per Nathanson, Kate Domchek, Susan Rebbeck, Tim Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Złowowcka-Perłowska, Elżbieta Osorio, Ana Durán, Mercedes Andrés, Raquel Benítez, Javier Hamann, Ute Hogervorst, Frans B van Os , Theo A Verhoef, Senno Meijers-Heijboer, Hanne EJ Wijnen, Juul Gómez Garcia, Encarna B Ligtenberg, Marjolijn J Kriege, Mieke Collée, J Margriet Ausems, Margreet GEM Oosterwijk, Jan C Peock, Susan Frost, Debra Ellis, Steve D Platte, Radka Fineberg, Elena Evans, D Gareth Lalloo, Fiona Jacobs, Chris Eeles, Ros Adlard, Julian Davidson, Rosemarie Cole, Trevor Cook, Jackie Paterson, Joan Douglas, Fiona Brewer, Carole Hodgson, Shirley Morrison, Patrick J Walker, Lisa Rogers, Mark T Donaldson, Alan Dorkins, Huw Godwin, Andrew K Bove, Betsy Stoppa-Lyonnet, Dominique Houdayer, Claude Buecher, Bruno de Pauw, Antoine Mazoyer, Sylvie Calender, Alain Léoné, Mélanie Bressac- de Paillerets, Brigitte Caron, Olivier Sobol, Hagay Frenay, Marc Prieur, Fabienne Ferrer, Sandra Fert Mortemousque, Isabelle Buys, Saundra Daly, Mary Miron, Alexander Terry, Mary Beth Hopper, John L John, Esther M Southey, Melissa Goldgar, David Singer, Christian F Fink-Retter, Anneliese Tea, Muy-Kheng Kaulich, Daphne Geschwantler Hansen, Thomas VO Nielsen, Finn C Barkardottir, Rosa B Gaudet, Mia Kirchhoff, Tomas Joseph, Vijai Dutra-Clarke, Ana Offit, Kenneth Piedmonte, Marion Kirk, Judy Cohn, David Hurteau, Jean Byron, John Fiorica, James Toland, Amanda E Montagna, Marco Oliani, Cristina Imyanitov, Evgeny Isaacs, Claudine Tihomirova, Laima Blanco, Ignacio Lazaro, Conxi Teulé, Alex Valle, J Del Gayther, Simon A Odunsi, Kunle Gross, Jenny Karlan, Beth Y Olah, Edith Teo, Soo-Hwang Ganz, Patricia A Beattie, Mary S Dorfling, Cecelia M van Rensburg, Elizabeth Jansen Diez, Orland Kwong, Ava Schmutzler, Rita K Wappenschmidt, Barbara Engel, Christoph Meindl, Alfons Ditsch, Nina Arnold, Norbert Heidemann, Simone Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorothea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Fiebig, Britta Schäfer, Dieter Caldes, Trinidad de la Hoya, Miguel Nevanlinna, Heli Muranen, Taru A Lespérance, Bernard Spurdle, Amanda B Neuhausen, Susan L Ding, Yuan C Wang, Xianshu Fredericksen, Zachary Pankratz, Vernon S Lindor, Noralane M Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Bonanni, Bernardo Bernard, Loris Dolcetti, Riccardo Papi, Laura Ottini, Laura Radice, Paolo Greene, Mark H Loud, Jennifer T Andrulis, Irene L Ozcelik, Hilmi Mulligan, Anna Marie Glendon, Gord Thomassen, Mads Gerdes, Anne-Marie Jensen, Uffe B Skytte, Anne-Bine Kruse, Torben A Chenevix-Trench, Georgia Couch, Fergus J Simard, Jacques Easton, Douglas F Breast Cancer Res Research Article INTRODUCTION: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2). METHODS: To evaluate whether these single nucleotide polymorphisms (SNPs) are associated with breast cancer risk for BRCA1 and BRCA2 carriers, we genotyped these SNPs in 12,599 BRCA1 and 7,132 BRCA2 mutation carriers and analysed the associations with breast cancer risk within a retrospective likelihood framework. RESULTS: Only SNP rs10771399 near PTHLH was associated with breast cancer risk for BRCA1 mutation carriers (per-allele hazard ratio (HR) = 0.87, 95% CI: 0.81 to 0.94, P-trend = 3 × 10(-4)). The association was restricted to mutations proven or predicted to lead to absence of protein expression (HR = 0.82, 95% CI: 0.74 to 0.90, P-trend = 3.1 × 10(-5), P-difference = 0.03). Four SNPs were associated with the risk of breast cancer for BRCA2 mutation carriers: rs10995190, P-trend = 0.015; rs1011970, P-trend = 0.048; rs865686, 2df-P = 0.007; rs1292011 2df-P = 0.03. rs10771399 (PTHLH) was predominantly associated with estrogen receptor (ER)-negative breast cancer for BRCA1 mutation carriers (HR = 0.81, 95% CI: 0.74 to 0.90, P-trend = 4 × 10(-5)) and there was marginal evidence of association with ER-negative breast cancer for BRCA2 mutation carriers (HR = 0.78, 95% CI: 0.62 to 1.00, P-trend = 0.049). CONCLUSIONS: The present findings, in combination with previously identified modifiers of risk, will ultimately lead to more accurate risk prediction and an improved understanding of the disease etiology in BRCA1 and BRCA2 mutation carriers. BioMed Central 2012 2012-02-20 /pmc/articles/PMC3496151/ /pubmed/22348646 http://dx.doi.org/10.1186/bcr3121 Text en Copyright © 2012 Antoniou et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Antoniou, Antonis C Kuchenbaecker, Karoline B Soucy, Penny Beesley, Jonathan Chen, Xiaoqing McGuffog, Lesley Lee, Andrew Barrowdale, Daniel Healey, Sue Sinilnikova, Olga M Caligo, Maria A Loman, Niklas Harbst, Katja Lindblom, Annika Arver, Brita Rosenquist, Richard Karlsson, Per Nathanson, Kate Domchek, Susan Rebbeck, Tim Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Złowowcka-Perłowska, Elżbieta Osorio, Ana Durán, Mercedes Andrés, Raquel Benítez, Javier Hamann, Ute Hogervorst, Frans B van Os , Theo A Verhoef, Senno Meijers-Heijboer, Hanne EJ Wijnen, Juul Gómez Garcia, Encarna B Ligtenberg, Marjolijn J Kriege, Mieke Collée, J Margriet Ausems, Margreet GEM Oosterwijk, Jan C Peock, Susan Frost, Debra Ellis, Steve D Platte, Radka Fineberg, Elena Evans, D Gareth Lalloo, Fiona Jacobs, Chris Eeles, Ros Adlard, Julian Davidson, Rosemarie Cole, Trevor Cook, Jackie Paterson, Joan Douglas, Fiona Brewer, Carole Hodgson, Shirley Morrison, Patrick J Walker, Lisa Rogers, Mark T Donaldson, Alan Dorkins, Huw Godwin, Andrew K Bove, Betsy Stoppa-Lyonnet, Dominique Houdayer, Claude Buecher, Bruno de Pauw, Antoine Mazoyer, Sylvie Calender, Alain Léoné, Mélanie Bressac- de Paillerets, Brigitte Caron, Olivier Sobol, Hagay Frenay, Marc Prieur, Fabienne Ferrer, Sandra Fert Mortemousque, Isabelle Buys, Saundra Daly, Mary Miron, Alexander Terry, Mary Beth Hopper, John L John, Esther M Southey, Melissa Goldgar, David Singer, Christian F Fink-Retter, Anneliese Tea, Muy-Kheng Kaulich, Daphne Geschwantler Hansen, Thomas VO Nielsen, Finn C Barkardottir, Rosa B Gaudet, Mia Kirchhoff, Tomas Joseph, Vijai Dutra-Clarke, Ana Offit, Kenneth Piedmonte, Marion Kirk, Judy Cohn, David Hurteau, Jean Byron, John Fiorica, James Toland, Amanda E Montagna, Marco Oliani, Cristina Imyanitov, Evgeny Isaacs, Claudine Tihomirova, Laima Blanco, Ignacio Lazaro, Conxi Teulé, Alex Valle, J Del Gayther, Simon A Odunsi, Kunle Gross, Jenny Karlan, Beth Y Olah, Edith Teo, Soo-Hwang Ganz, Patricia A Beattie, Mary S Dorfling, Cecelia M van Rensburg, Elizabeth Jansen Diez, Orland Kwong, Ava Schmutzler, Rita K Wappenschmidt, Barbara Engel, Christoph Meindl, Alfons Ditsch, Nina Arnold, Norbert Heidemann, Simone Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorothea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Fiebig, Britta Schäfer, Dieter Caldes, Trinidad de la Hoya, Miguel Nevanlinna, Heli Muranen, Taru A Lespérance, Bernard Spurdle, Amanda B Neuhausen, Susan L Ding, Yuan C Wang, Xianshu Fredericksen, Zachary Pankratz, Vernon S Lindor, Noralane M Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Bonanni, Bernardo Bernard, Loris Dolcetti, Riccardo Papi, Laura Ottini, Laura Radice, Paolo Greene, Mark H Loud, Jennifer T Andrulis, Irene L Ozcelik, Hilmi Mulligan, Anna Marie Glendon, Gord Thomassen, Mads Gerdes, Anne-Marie Jensen, Uffe B Skytte, Anne-Bine Kruse, Torben A Chenevix-Trench, Georgia Couch, Fergus J Simard, Jacques Easton, Douglas F Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers |
| title | Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers |
| title_full | Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers |
| title_fullStr | Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers |
| title_full_unstemmed | Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers |
| title_short | Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers |
| title_sort | common variants at 12p11, 12q24, 9p21, 9q31.2 and in znf365 are associated with breast cancer risk for brca1 and/or brca2 mutation carriers |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496151/ https://www.ncbi.nlm.nih.gov/pubmed/22348646 http://dx.doi.org/10.1186/bcr3121 |
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commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT ligtenbergmarjolijnj commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT kriegemieke commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT colleejmargriet commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT ausemsmargreetgem commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT oosterwijkjanc commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT peocksusan commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT frostdebra commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT ellissteved commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT platteradka commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT finebergelena commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT evansdgareth commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT lalloofiona commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT jacobschris commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT eelesros commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT adlardjulian commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT davidsonrosemarie commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT coletrevor commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT cookjackie commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT patersonjoan commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT douglasfiona commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT brewercarole commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT hodgsonshirley commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT morrisonpatrickj commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT walkerlisa commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT rogersmarkt commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT donaldsonalan commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT dorkinshuw commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT godwinandrewk commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT bovebetsy commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT stoppalyonnetdominique commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT houdayerclaude commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT buecherbruno commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT depauwantoine commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT mazoyersylvie commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT calenderalain commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT leonemelanie commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT bressacdepailleretsbrigitte commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT caronolivier commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT sobolhagay commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT frenaymarc commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT prieurfabienne commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT ferrersandrafert commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT mortemousqueisabelle commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT buyssaundra commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT dalymary commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT mironalexander commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT terrymarybeth commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT hopperjohnl commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT johnestherm commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT southeymelissa commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT goldgardavid commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT singerchristianf commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT finkretteranneliese commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT teamuykheng commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT kaulichdaphnegeschwantler commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT hansenthomasvo commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT nielsenfinnc commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT barkardottirrosab commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT gaudetmia commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT kirchhofftomas commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT josephvijai commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT dutraclarkeana commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT offitkenneth commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT piedmontemarion commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT kirkjudy commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT cohndavid commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT hurteaujean commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT byronjohn commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT fioricajames commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT tolandamandae commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT montagnamarco commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT olianicristina commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT imyanitovevgeny commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT isaacsclaudine commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT tihomirovalaima commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT blancoignacio commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT lazaroconxi commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT teulealex commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT vallejdel commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT gaythersimona commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT odunsikunle commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT grossjenny commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT karlanbethy commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT olahedith commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT teosoohwang commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT ganzpatriciaa commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT beattiemarys commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT dorflingceceliam commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT vanrensburgelizabethjansen commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT diezorland commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT kwongava commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT schmutzlerritak commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT wappenschmidtbarbara commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT engelchristoph commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT meindlalfons commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT ditschnina commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT arnoldnorbert commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT heidemannsimone commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT niederacherdieter commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT preisleradamssabine commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT gadzickidorothea commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT varonmateevaraymonda commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT deisslerhelmut commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT gehrigandrea commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT sutterchristian commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT kastkarin commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT fiebigbritta commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT schaferdieter commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT caldestrinidad commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT delahoyamiguel commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT nevanlinnaheli commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT muranentarua commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT lesperancebernard commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT spurdleamandab commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT neuhausensusanl commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT dingyuanc commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT wangxianshu commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT fredericksenzachary commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT pankratzvernons commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT lindornoralanem commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT peterlongopaolo commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT manoukiansiranoush commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT peisselbernard commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT zaffaronidaniela commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT bonannibernardo commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT bernardloris commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT dolcettiriccardo commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT papilaura commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT ottinilaura commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT radicepaolo commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT greenemarkh commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT loudjennifert commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT andrulisirenel commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT ozcelikhilmi commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT mulliganannamarie commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT glendongord commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT thomassenmads commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT gerdesannemarie commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT jensenuffeb commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT skytteannebine commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT krusetorbena commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT chenevixtrenchgeorgia commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT couchfergusj commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT simardjacques commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers AT eastondouglasf commonvariantsat12p1112q249p219q312andinznf365areassociatedwithbreastcancerriskforbrca1andorbrca2mutationcarriers |