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Inhibition of cytosolic Phospholipase A(2) prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin

BACKGROUND: Activation of phospholipase A(2) (PLA(2)) and the subsequent metabolism of arachidonic acid (AA) to prostaglandins have been shown to play an important role in neuronal death in neurodegenerative disease. Here we report the effects of the prion peptide fragment HuPrP106-126 on the PLA(2)...

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Detalles Bibliográficos
Autores principales:	Last, Victoria, Williams, Alun, Werling, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496594/ https://www.ncbi.nlm.nih.gov/pubmed/22928663 http://dx.doi.org/10.1186/1471-2202-13-106

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