Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

BACKGROUND: A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations selected by cytotoxic T lymphocytes (CTL) on viral fitness in the context of the...

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Detalles Bibliográficos
Autores principales: Song, Hongshuo, Pavlicek, Jeffrey W, Cai, Fangping, Bhattacharya, Tanmoy, Li, Hui, Iyer, Shilpa S, Bar, Katharine J, Decker, Julie M, Goonetilleke, Nilu, Liu, Michael KP, Berg, Anna, Hora, Bhavna, Drinker, Mark S, Eudailey, Josh, Pickeral, Joy, Moody, M Anthony, Ferrari, Guido, McMichael, Andrew, Perelson, Alan S, Shaw, George M, Hahn, Beatrice H, Haynes, Barton F, Gao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496648/
https://www.ncbi.nlm.nih.gov/pubmed/23110705
http://dx.doi.org/10.1186/1742-4690-9-89

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